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anti-PLEC 抗体

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton.

46 results:

anti-PLEC 抗体 (Plectin) (AA 2644-2671) Primary Antibody

PLEC 适用: 人, 小鼠, 大鼠 IHC (p), WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043900
$280.00
加上运输费 $45.00
100 μg
local_shipping 发货至: 美国
4至6个工作日

anti-PLEC 抗体 (Plectin) (AA 4384-4493) Primary Antibody

PLEC 适用: 人 IF, ELISA, WB 宿主: 小鼠 Monoclonal 4C3 unconjugated
产品编号 ABIN518954
$600.00
加上运输费 $45.00
100 μg
local_shipping 发货至: 美国
11至12个工作日

anti-PLEC 抗体 (Plectin) (Asp175) Primary Antibody

PLEC 适用: 人 ICC, IHC, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1869850
$245.00
加上运输费 $45.00
100 μL (More quantities available)
local_shipping 发货至: 美国
10至13个工作日

anti-PLEC 抗体 (Plectin) (AA 4384-4493) Primary Antibody

PLEC 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4D12 unconjugated
产品编号 ABIN518953
$600.00
加上运输费 $45.00
100 μg
local_shipping 发货至: 美国
11至12个工作日

anti-PLEC 抗体 (Plectin) (AA 240-320) Primary Antibody

PLEC 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6389102
$367.82
加上运输费 $45.00
100 μL (More quantities available)
local_shipping 发货至: 美国
11至13个工作日

anti-PLEC 抗体 (Plectin) (C-Term) Primary Antibody

PLEC 适用: 人 IHC (fro), IHC (p), WB 宿主: 豚鼠 Polyclonal unconjugated
产品编号 ABIN285899
$883.04
加上运输费 $45.00
100 μL
local_shipping 发货至: 美国
9至11个工作日

anti-PLEC 抗体 (Plectin) Primary Antibody

PLEC 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264300
$390.77
加上运输费 $45.00
100 μL (More quantities available)
local_shipping 发货至: 美国
8至9个工作日

anti-PLEC 抗体 (Plectin) (AA 4367-684) Primary Antibody

PLEC 适用: 人, 鱼, 非洲爪蟾 IHC (fro), IF, IHC (p), WB 宿主: 豚鼠 Polyclonal unconjugated
Pubmed 1
产品编号 ABIN113466
$462.00
加上运输费 $45.00
0.1 mL
local_shipping 发货至: 美国
6至8个工作日

anti-PLEC 抗体 (Plectin) (AA 4384-4493) Primary Antibody

PLEC 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
产品编号 ABIN562270
$465.71
加上运输费 $45.00
50 μL
local_shipping 发货至: 美国
11至12个工作日

anti-PLEC 抗体 (Plectin) Primary Antibody

PLEC 适用: 人, 小鼠, 大鼠 IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN701965
$339.90
加上运输费 $45.00
100 μL
local_shipping 发货至: 美国
4至6个工作日
  • 类型 Primary
    • Primary
  • 抗原 Plectin (PLEC)
    • Plectin (PLEC)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • CD4 Molecule (CD4)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Tumor Necrosis Factor alpha (TNF)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Nuclear Factor-KB P65 (NFkBP65)
    • Interferon gamma (IFNG)
    • Estrogen Receptor 1 (ESR1)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Albumin (ALB)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Integrin alpha M (ITGAM)
    • CD8
    • CD44
    • Histone H4
    • Jun Proto-Oncogene (JUN)
    • Myc Proto-Oncogene protein (MYC)
    • Interleukin 6 (IL6)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Catenin, beta
    • Interleukin 2 Receptor, alpha (IL2RA)
    • Mucin 1, Cell Surface Associated (MUC1)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Vimentin (VIM)
    • CD5 Molecule (CD5)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD3
    • Insulin Receptor Substrate 1 (IRS1)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Glial Fibrillary Acidic Protein (GFAP)
    • CD34
    • Interleukin 2 (IL2)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • Keratin 18 (KRT18)
    • CD14
    • Synuclein, alpha (SNCA)
  • 应用范围
    • Western Blotting (WB)
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • ELISA
    • Immunohistochemistry (IHC)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Immunofluorescence (IF)
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Flow Cytometry (FACS)
    • Immunocytochemistry (ICC)
    • Immunofluorescence (fixed cells) (IF/ICC)
  • 适用
    • 小鼠
    • 大鼠
    • 非洲爪蟾
    • Cow
  • 论文引用
  • 图像
  • 抗体来源
    • 豚鼠
    • 小鼠
  • 克隆形成能力
    • Polyclonal
    • Monoclonal
  • 克隆
    • 4D12
    • 10F301
    • 4C3
    • 6D75
    • RB56747
  • 抗原表位
    • C-Term
    • AA 1744-1929
    • AA 4367-4684
    • AA 4384-4493
    • AA 240-320
    • AA 2644-2671
    • AA 4241-4275
    • AA 4367-684
    • AA 4384-4494
    • Asp175
    • Middle Region
  • 标记
    • 非结合性
    • Biotin
    • Alexa Fluor 750
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • FITC
    • HRP
    • Alexa Fluor 350
    • Cy3
    • Cy5
    • Cy5.5
    • Cy7
  • 抗体亚型
    • IgG
    • IgG2a kappa
    • IgG1
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized

PLEC 抗原简介

蛋白简介

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Gene names and symbols associated with anti-Plectin (PLEC) 抗体

  • plectin (LOC100481602) 抗体
  • plectin L homeolog (plec.L) 抗体
  • plectin (PLEC) 抗体
  • plectin (Plec) 抗体
  • plectin (LOC786966) 抗体
  • AA591047 抗体
  • AU042537 抗体
  • EBS1 抗体
  • EBSO 抗体
  • HD1 抗体
  • IFAP300 抗体
  • LGMD2Q 抗体
  • Pcn 抗体
  • Plec1 抗体
  • PLEC1b 抗体
  • Plectin-1 抗体
  • Pltn 抗体

Protein level used designations for anti-Plectin (PLEC) 抗体

plectin , plectin-1-like , hemidesmosomal protein 1 , plectin 1, intermediate filament binding protein 500kDa , plectin-1 , plectin 1 , plectin-6 , 300 kDa intermediate filament-associated protein

GENE ID SPECIES
100481602 Ailuropoda melanoleuca
398587 Xenopus laevis
5339 Homo sapiens
18810 Mus musculus
64204 Rattus norvegicus
100682530 Cricetulus griseus
786966 Bos taurus
482083 Canis lupus familiaris

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