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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. 再加上，我们可以发PTTG1 抗体 (77) 和 PTTG1 蛋白 (15)和数多这个蛋白质的别的产品。
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High PTTG1 expression is associated with aggressive meningiomas.
These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (显示 TRIB1 ELISA试剂盒) and TRb2 (显示 TRIB2 ELISA试剂盒)-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.
Findings indicate that PBF (显示 PTTG1IP ELISA试剂盒) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
PTTG-mediated FGF2 (显示 FGF2 ELISA试剂盒) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.
All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain (显示 ITSN1 ELISA试剂盒), which may mediate the intermolecular recognition between hPTTG1 and MAP3K.
that PTTG1 is a novel downstream target gene of androgen receptor (显示 AR ELISA试剂盒) and take part in prostate cancer proliferation and metastasis
Knockdown of PTTG1 suppresses the growth and invasion of LAC (显示 LCT ELISA试剂盒) cells through upregulation of the TGFbeta1 (显示 TGFB1 ELISA试剂盒)/SMAD3 (显示 SMAD3 ELISA试剂盒) signaling.
PTTG1 is correlated with non-small cell lung cancer (NSCLC) progression and as an independent poor prognostic factor in NSCLC patients.
Our data indicate that securin expression may serve as a strong and independent prognosticator of breast cancer outcome
PTTG1 is a new candidate maternal effect (显示 NLRP5 ELISA试剂盒) gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis
High PTTG1 expression is associated with pituitary tumor development.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
RasGrf1 (显示 RASGRF1 ELISA试剂盒) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.
Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis
PBF (显示 PTTG1IP ELISA试剂盒) is the first protein to interact with the critical TH transporter MCT8 (显示 MCT8 ELISA试剂盒) and modulate its function in vivo
CSN3 (显示 CSN3 ELISA试剂盒) and CSN5 (显示 COPS5 ELISA试剂盒) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (显示 CCNB1 ELISA试剂盒) and Securin via APC (显示 APC ELISA试剂盒)/C.
The genetically deleting Tff3 (显示 TFF3 ELISA试剂盒) in mice altered down-regulated Pttg1 and up-regulated serpina3n (显示 SERPINA3N ELISA试剂盒) expression, indicating a potential role of these factors during the development of presbyacusis.
data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function
Pituitary tumor transforming gene 1 (PTTG1), an oncogene (显示 RAB1A ELISA试剂盒), was the most up-regulated transcript in KLF6 (显示 KLF6 ELISA试剂盒)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (显示 KLF6 ELISA试剂盒).
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
pituitary tumor-transforming protein 1
, pituitary tumor-transforming 1
, ESP1-associated protein 1
, pituitary tumor-transforming gene 1 protein
, tumor-transforming protein 1
, Pituitary tumor transforming