Pituitary Tumor-Transforming 1 (PTTG1) ELISA试剂盒

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. 再加上,我们可以发PTTG1 抗体 (87)PTTG1 蛋白 (17)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
PTTG1 9232 O95997
PTTG1 30939 Q9CQJ7
PTTG1 64193 P97613
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Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. Data strongly indicated that PTTG1 is a target gene of miR186 in osteosarcoma (OS) cells and is involved in miR186mediated suppressive effects of OS cells.

  2. Results show that PTTG1 oncoprotein overexpression may modulate cell proliferation-related regulators in myeloid leukemia (显示 BCL11A ELISA试剂盒).

  3. In ACTH (显示 POMC ELISA试剂盒)-secreting pituitary tumors, IHC staining showed strong cytoplasmic and moderate nucleic PTTG immunoreactivity in 22 of 28 nonrecurrent tumors and in 21 of 27 recurrent tumors but no staining in the 2 normal pituitaries. PTTG was significantly increased in both the nonrecurrent and recurrent groups compared with normal pituitary glands, but there was no difference between the nonrecurrent and recurrent groups.

  4. Smurf1 (显示 SMURF1 ELISA试剂盒) interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  5. PTTG-1 oexpression in meningiomas were correlated with tumor grade and proliferation rate.

  6. Results found that PTTG1 expression was significantly increased in androgen-independent prostate cancer cells and, elucidates that interleukin-6 (显示 IL6 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) activation can increase PTTG1 expression and, consequently, promote the resistance to androgen deprivation therapy in castration-resistant prostate cancer by inducing EMT (显示 ITK ELISA试剂盒) and increasing the cancer stem cell population.

  7. we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR (显示 MLXIP ELISA试剂盒)-146a-3p.

  8. PTTG1 is an independent prognostic factor and acts as an oncogene (显示 RAB1A ELISA试剂盒) in colorectal cancer

  9. High PTTG1 expression is associated with aggressive meningiomas.

  10. These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. Smurf1 (显示 SMURF1 ELISA试剂盒) interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  2. High PTTG1 expression is associated with pituitary tumor development.

  3. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  4. RasGrf1 (显示 RASGRF1 ELISA试剂盒) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  5. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  6. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  7. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo

  8. CSN3 (显示 CSN3 ELISA试剂盒) and CSN5 (显示 COPS5 ELISA试剂盒) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (显示 CCNB1 ELISA试剂盒) and Securin via APC (显示 APC ELISA试剂盒)/C.

  9. The genetically deleting Tff3 (显示 TFF3 ELISA试剂盒) in mice altered down-regulated Pttg1 and up-regulated serpina3n (显示 SERPINA3N ELISA试剂盒) expression, indicating a potential role of these factors during the development of presbyacusis.

  10. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

PTTG1 抗原简介

Antigen Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1) 抗体
  • pituitary tumor-transforming gene 1 (Pttg1) 抗体
  • pituitary tumor-transforming 1 (Pttg1) 抗体
  • securin, sister chromatid separation inhibitor (cut2) 抗体
  • AW555095 抗体
  • C87862 抗体
  • EAP1 抗体
  • HPTTG 抗体
  • Protein Cut2 抗体
  • Pttg 抗体
  • PTTG1 抗体
  • Pttg3 抗体
  • Securin 抗体
  • TUTR1 抗体

Protein level used designations for PTTG1

ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , securin , tumor-transforming protein 1 , pituitary tumor-transforming protein 1 , pituitary tumor-transforming 1 , Pituitary tumor transforming , Pituitary tumor-transforming gene 1 protein , Cell untimely torn protein 2

GENE ID SPECIES
9232 Homo sapiens
397015 Sus scrofa
416158 Gallus gallus
479307 Canis lupus familiaris
508043 Bos taurus
696143 Macaca mulatta
30939 Mus musculus
64193 Rattus norvegicus
462238 Pan troglodytes
100848911 Bos taurus
2539641 Schizosaccharomyces pombe 972h-
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