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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. 再加上，我们可以发PTTG1 抗体 (74) 和 PTTG1 蛋白 (15)和数多这个蛋白质的别的产品。
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PTTG-1 oexpression in meningiomas were correlated with tumor grade and proliferation rate.
Results found that PTTG1 expression was significantly increased in androgen-independent prostate cancer cells and, elucidates that interleukin-6 (显示 IL6 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) activation can increase PTTG1 expression and, consequently, promote the resistance to androgen deprivation therapy in castration-resistant prostate cancer by inducing EMT (显示 ITK ELISA试剂盒) and increasing the cancer stem cell population.
we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR (显示 MLXIP ELISA试剂盒)-146a-3p.
PTTG1 is an independent prognostic factor and acts as an oncogene (显示 RAB1A ELISA试剂盒) in colorectal cancer
High PTTG1 expression is associated with aggressive meningiomas.
These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 and TRb2-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.
Findings indicate that PBF (显示 PTTG1IP ELISA试剂盒) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
PTTG-mediated FGF2 (显示 FGF2 ELISA试剂盒) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.
All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain (显示 ITSN1 ELISA试剂盒), which may mediate the intermolecular recognition between hPTTG1 and MAP3K.
PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis
High PTTG1 expression is associated with pituitary tumor development.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
RasGrf1 (显示 RASGRF1 ELISA试剂盒) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.
Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis
PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo
CSN3 (显示 CSN3 ELISA试剂盒) and CSN5 (显示 COPS5 ELISA试剂盒) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (显示 CCNB1 ELISA试剂盒) and Securin via APC (显示 APC ELISA试剂盒)/C.
The genetically deleting Tff3 (显示 TFF3 ELISA试剂盒) in mice altered down-regulated Pttg1 and up-regulated serpina3n (显示 SERPINA3N ELISA试剂盒) expression, indicating a potential role of these factors during the development of presbyacusis.
data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function
Pituitary tumor transforming gene 1 (PTTG1), an oncogene (显示 RAB1A ELISA试剂盒), was the most up-regulated transcript in KLF6+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6.
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
ESP1-associated protein 1
, pituitary tumor-transforming gene 1 protein
, tumor-transforming protein 1
, pituitary tumor-transforming protein 1
, pituitary tumor-transforming 1
, Pituitary tumor transforming
, Pituitary tumor-transforming gene 1 protein
, Cell untimely torn protein 2