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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 再加上，我们可以发PIEZO1 抗体 (42) 和 PIEZO1 蛋白 (3)和数多这个蛋白质的别的产品。
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Piezo1 plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12 (显示 CASP12 ELISA试剂盒)-dependent pathway.
MiR (显示 MLXIP ELISA试剂盒)-103a might be a potential biomarker of myocardium infarction and could be used as an index for the diagnosis of AMI (显示 CFD ELISA试剂盒). It may be involved in the development of HBP (显示 AZU1 ELISA试剂盒) and onset of AMI (显示 CFD ELISA试剂盒) through regulating the Piezo1 expression.
The structural dynamics of the PIEZO1 channel activation and inactivation by coarse-grained modeling has been reported.
Additional alterations in mutant PIEZO1 channel kinetics, differences in response to osmotic stress, and altered membrane protein trafficking, predicting variant alleles that worsen or ameliorate erythrocyte hydration.
differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II.
data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.
The Piezo1 convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.
Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.
platelets and Meg (显示 PTPN4 ELISA试剂盒)-01 cells express the MS cation channel (显示 TRPV1 ELISA试剂盒) Piezo1, which may contribute to Ca(2 (显示 CA2 ELISA试剂盒)+) entry and thrombus formation under arterial shear.
correlation between HPCHA and PIEZO1-gene mutated findings raise an important question as to whether any of the high phosphatidylcholine (显示 SGMS2 ELISA试剂盒) hemolytic anemia cases previously diagnosed in Japan may have in fact been the form of hemolytic anemia known as hereditary xerocytosis or dehydrated hereditary stomatocytosis with PIEZO1 gene mutation
Both TRPV4 (显示 TRPV4 ELISA试剂盒) and PIEZO1 channels contribute to currents activated by stimuli applied at cell-substrate contacts but only PIEZO1 mediates stretch-activated currents. These data demonstrate that there are separate, but overlapping, mechanoelectrical transduction pathways in chondrocytes.
Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.
Our results suggest that Piezo1 is unlikely to be a component of the mechanoelectrical transducer channel complex in mammalian cochlear outer hair cells
Smooth muscle Piezo1 is required for stretch-activated cationic channel activity. PIezo1 is involved in the remodeling of small arteries.
This study demonstrated that Piezo1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.
cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A
Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells
Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow.
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010
family with sequence similarity 38, member A
, membrane protein induced by beta-amyloid treatment
, protein PIEZO1