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The tumor suppressor WT1 represses and activates transcription. 再加上，我们可以发PAWR 抗体 (74) 和 PAWR 蛋白 (4)和数多这个蛋白质的别的产品。
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we determined that increased miR-17-3P level plays crucial role in CRC (显示 CALR ELISA试剂盒) cells survival by targeting Par4, contributing to colorectal carcinogenesis.
PAR4 is the target of mir-107 in colorectal cancer cells.
we confirmed that the RASSF2-PAR-4 axis was mainly responsible for miR-7 functions in CAFs using bioinformatics methods. Overexpression of miR-7 in CAFs led to down-regulation of RASSF2, which dramatically decreased the secretion of PAR-4 from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells.
we investigated in the present study the mechanisms regulating the accumulation of a 25kDa cleaved-Par-4 (cl-Par-4) fragment in ovarian and endometrial cancer cell lines
Authors demonstrate that TRIM21 (显示 TRIM21 ELISA试剂盒) expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.
Data suggest that PAR4 and P2Y12 (显示 P2RY12 ELISA试剂盒) heterodimer internalization/endocytosis is required for beta-arrestin-2 (显示 ARRB2 ELISA试剂盒) recruitment to endosomes and up-regulation of Akt (显示 AKT1 ELISA试剂盒) signaling; activation of PAR4 but not of P2Y12 (显示 P2RY12 ELISA试剂盒) drives internalization of the PAR4-P2Y12 (显示 P2RY12 ELISA试剂盒) heterodimer. (PAR4 = protease-activated receptor 4 (显示 F2RL3 ELISA试剂盒); P2Y12 (显示 P2RY12 ELISA试剂盒) = purinergic receptor P2Y (显示 P2RY1 ELISA试剂盒), G-protein coupled, 12 protein; Akt (显示 AKT1 ELISA试剂盒) = proto-oncogene (显示 RAB1A ELISA试剂盒) protein c-akt (显示 AKT1 ELISA试剂盒))
In this review, we will focus on the therapeutic perspective of Par-4 with a special reference to its (Par-4) virgin prospect of devastating metastasis control.
in vitro and in vivo upregulation of Par-4 expression is indispensable for the trafficking of GRP78 (显示 HSPA5 ELISA试剂盒) to the cell membrane and subsequent apoptosis of cancer cell
Prostate apoptosis response 4 (PAR4) expression modulates WNT (显示 WNT2 ELISA试剂盒) signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity.
Decreased PAR4 expression in breast cancer is associated with shorter survival. PAR4 suppresses growth and invasiveness of breast cancer cells.
Induced by endoplasmic reticulum stress Par-4 (显示 F2RL3 ELISA试剂盒) acts as an important defense mechanism against mycobacterial infection and regulates cancer.
Findings reveal a novel role for Par-4 (显示 F2RL3 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) in islet beta cell apoptosis and type 2 diabetes.
Par4 (显示 F2RL3 ELISA试剂盒), CEBPB (显示 CEBPB ELISA试剂盒) and FAK (显示 PTK2 ELISA试剂盒) form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (显示 ITK ELISA试剂盒) and self-renewal
a novel mechanism of apoptosis induction by PAR-4 (显示 F2RL3 ELISA试剂盒)/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease.
extracellular Par-4 (显示 F2RL3 ELISA试剂盒)/SAC (显示 ADCY10 ELISA试剂盒) is systemically functional in inhibition of tumor growth and metastasis progression.
loss of PAR4 (显示 F2RL3 ELISA试剂盒) leads to a reduction in the ability of tumour necrosis factor-alpha (显示 TNF ELISA试剂盒) to induce apoptosis by increased activation of NF-kappaB (显示 NFKB1 ELISA试剂盒)
Antisense knockdown of PAR-4 (显示 F2RL3 ELISA试剂盒) or inhibition of ceramide biosynthesis reduced stem cell apoptosis; PAR-4 (显示 F2RL3 ELISA试剂盒) overexpression and treatment with ceramide analogs elevated apoptosis.
AATF (显示 AATF ELISA试剂盒) is an endogenous antagonist of Par-4 (显示 F2RL3 ELISA试剂盒) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Par-4 (显示 F2RL3 ELISA试剂盒) is directly involved in regulating choline uptake by interacting with CHT1 (显示 ChT ELISA试剂盒) and by reducing its incorporation on the cell surface
the mechanism for Ras-mediated down-regulation of Par-4 (显示 F2RL3 ELISA试剂盒) is by promoter methylation
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
PRKC, apoptosis, WT1, regulator
, PRKC apoptosis WT1 regulator protein
, PRKC, apoptosis, WT1, regulator like
, WT1-interacting protein
, prostate apoptosis response 4 protein
, prostate apoptosis response protein 4
, prostate apoptosis response protein PAR-4
, prostate apoptosis response-4
, transcriptional repressor PAR4
, Prostate apoptosis response protein 4
, par-4 induced by effectors of apoptosis
, transcriptional repressor Par-4-like protein PAWR