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Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis.
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Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).
Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells.
To further understand its functions in CML (显示 BCR ELISA试剂盒) pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development.
Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders.
In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 is activated, leading to the inhibition of global protein synthesis and increased AZ1 synthesis via a cap-independent mechanism.
AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC (显示 ODC1 ELISA试剂盒) and AZI and inhibition of their function.
the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities
Data show that OAZ promotes the removal of Mps1 (显示 IDUA ELISA试剂盒) from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1 (显示 IDUA ELISA试剂盒).
These data together demonstrate the existence of a c-Jun (显示 JUN ELISA试剂盒)-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.
Human AZI is capable of acting as a general inhibitor for all members of the antizyme family.
Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences
Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53 (显示 TP53 ELISA试剂盒).
The activity of AZ1 was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation.
Testosterone treatment enhanced AZ1 and N1-SSAT (显示 SAT1 ELISA试剂盒) mRNA levels in a time-dependent manner
antizyme and glycosaminoglycans have roles in polyamine transport
OAZ can alter the intensity and duration of the BMP4 (显示 BMP4 ELISA试剂盒) stimulus through Smad6 (显示 SMAD6 ELISA试剂盒)
Az-1 has a central and meaningful role in modulation of polyamine homeostasis, and in regulating cellular proliferation and transformation properties.
The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and Ornithine Decarboxylase (ODC (显示 ODC1 ELISA试剂盒)).
antizyme expression requires programmed,+1 ribosomal frameshifting
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.
, antizyme 1
, ODC antizyme
, ornithine decarboxylase antizyme 1