anti-Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) 抗体

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. 再加上,我们可以发NPRL2 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NPRL2 56032 Q9WUE4
NPRL2 10641 Q8WTW4
NPRL2 363138  
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antibodies-online.cn销售最多的anti-NPRL2 抗体

Showing 10 out of 100 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 IHC, WB WB Suggested Anti-TUSC4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  OVCAR-3 cell lysate NPRL2 is supported by BioGPS gene expression data to be expressed in OVCAR3 Rabbit Anti-TUSC4 Antibody      Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver   Observed Staining: Cytoplasm in hepatocytes, moderate signal, very low tissue distribution  Primary Antibody Concentration: 1:100  Secondary Antibody: Donkey anti-Rabbit-Cy3  Secondary Antibody Concentration: 1:200  Magnification: 20X  Exposure Time: 0.5 – 2.0 sec  Protocol located in Reviews and Data. 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-TUSC4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  NCI-H226 cell lysate 100 μL 2至3个工作日
山羊 非结合性 ELISA, WB ABIN238648 (0.1 ug/ml) staining of Human Muscle lysate (35 ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. 100 μg 6至7个工作日
非结合性 EIA, WB NPRL2 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the NPRL2 antibody detected the NPRL2 protein (arrow). 0.4 mL 6至8个工作日
非结合性 ELISA, WB 100 μL Available
Cow 非结合性 WB 100 μL 11至14个工作日
Bat 山羊 非结合性 ELISA, WB 100 μg 11至14个工作日
非结合性 ELISA, WB Western blot analysis of TUSC4 using HepG2 whole cell lysates 100 μL 11至12个工作日
Bat 非结合性 IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-NPR2L / TUSC4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this ... 100 μL 11至14个工作日
非结合性 WB Western blot analysis in HL-60 cell line lysates (35ug/lane). 400 μL 2至3个工作日

引用最多的anti-NPRL2 抗体

  1. Cow (Bovine) Polyclonal NPRL2 Primary Antibody for IHC, WB - ABIN2773969 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

  2. Human Polyclonal NPRL2 Primary Antibody for ELISA, WB - ABIN548072 : Ueda, Kawashima, Ohtani, Deng, Ravoori, Bankson, Gao, Girard, Minna, Roth, Kundra, Ji: The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells. in Cancer research 2006 (PubMed)


Human Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) interaction partners

  1. these results demonstrate a new role for the NPRL2, distinct from its function in mTORC1 regulation.

  2. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.

  3. overall, 63 distinct variants were identified: 53 in DEPDC5, three in NPRL2 and seven in NPRL3 . Among these, 46 were novel (including 39 single nucleotide variants and seven CNVs) and 16 were newly defined as recurrent variants; 34 were loss-of-function (LoF) variants (nonsense, splice-site, frameshift indels and CNVs).

  4. The expression level of NPRL2 was significantly up-regulated in prostate cancer and its high expression was correlated with poor prognosis.

  5. The high levels of NPRL2 expression in castrate-resistant prostate cancer promote resistance to Everolimus by enhancing autophagy.

  6. NPRL2 overexpression enhances sensitivity to CPT-11 treatment in colon cancer cells.

  7. We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.

  8. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia.

  9. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.

  10. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor.

  11. NPRL2 mutations are significant cause of focal epilepsy.

  12. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.

  13. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.

  14. Decreased expression of NPRL2 is associated with renal cancer.

  15. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.

  16. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer.

  17. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.

  18. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors.

  19. tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer

  20. Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources.

NPRL2 抗原简介


Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

Gene names and symbols associated with NPRL2

  • nitrogen permease regulator-like 2 (Nprl2) 抗体
  • NPR2 like, GATOR1 complex subunit S homeolog (nprl2.S) 抗体
  • NPR2 like, GATOR1 complex subunit (NPRL2) 抗体
  • NPR2-like, GATOR1 complex subunit (Nprl2) 抗体
  • NPR2 like, GATOR1 complex subunit (nprl2) 抗体
  • 2810446G01Rik 抗体
  • G21 抗体
  • im:6900399 抗体
  • NPR2 抗体
  • npr2l 抗体
  • TUSC4 抗体
  • zgc:153630 抗体

Protein level used designations for NPRL2

NPR2-like protein , gene 21 protein , nitrogen permase homolog , nitrogen permease regulator 2-like protein , tumor suppressor candidate 4 , 2810446G01Rik , G21 protein , homologous to yeast nitrogen permease (candidate tumor suppressor)

56032 Mus musculus
379794 Xenopus laevis
10641 Homo sapiens
476614 Canis lupus familiaris
508487 Bos taurus
363138 Rattus norvegicus
559391 Danio rerio
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