Has a omega-amidase activity. 再加上，我们可以发NIT2 蛋白 (13) 和 和数多这个蛋白质的别的产品。
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Human Monoclonal NIT2 Primary Antibody for FACS, IF - ABIN2727337
Cooper, Shurubor, Dorai, Pinto, Isakova, Deryabina, Denton, Krasnikov: ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases. in Amino acids 2016
Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways
Human NIT1/2 are not involved in the metabolism of vildagliptin.
The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates.
Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate
Data conclude that mammalian nitrilase 2 is omega-amidase.
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively (By similarity).
Nit protein 2
, Nitrilase homolog 2-A
, nitrilase homolog 2
, omega-amidase NIT2-A
, nitrilase family, member 2
, omega-amidase NIT2
, Nitrilase homolog 2