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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. 再加上，我们可以发NCF2 抗体 (49)和数多这个蛋白质的别的产品。
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analysis of NCF2, BCKDHB (显示 BCKDHB 蛋白) and BCKDHA (显示 BCKDHA 蛋白) in pig
We analyzed the clinical and laboratory findings of CGD (显示 CYBB 蛋白) with mutations in the NCF2 gene from amongst our cohort of CGD (显示 CYBB 蛋白) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (显示 NCF4 蛋白) and p67phox at the phagosomal membrane.
TLR4 (显示 TLR4 蛋白)- and TLR2-induced IRAK (显示 IRAK1 蛋白)-ERK (显示 EPHB2 蛋白) pathway cross-talks with p67phox-Nox-2 (显示 CYBB 蛋白) for reactive oxygen species generation, thus regulating IL-1beta (显示 IL1B 蛋白) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 蛋白) subunits p22(phox (显示 CYBA 蛋白)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA 蛋白)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (显示 DNAJC5 蛋白)-Gly-Cys (显示 DNAJC5 蛋白) triad in Nox2 (显示 CYBB 蛋白) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (显示 DNAJC5 蛋白)-Gly-Cys (显示 DNAJC5 蛋白). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (显示 NCF4 蛋白)/VAV1 (显示 VAV1 蛋白)/RAC1 NADPH oxidase (显示 NOX1 蛋白) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (显示 AKT1 蛋白)-GTP (显示 AK3 蛋白)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (显示 NOX1 蛋白) Nox2 (显示 CYBB 蛋白).
Four novel mutations in the NCF1 (显示 NCF1 蛋白), NCF2, and CYBB (显示 CYBB 蛋白) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (显示 NOX1 蛋白) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (显示 PLA2G2A 蛋白) activity, an interaction that could function to terminate the PLA2 (显示 PLA2G2A 蛋白)-mediated NOX2 (显示 CYBB 蛋白) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (显示 FDXR 蛋白) oxidasesubunit (67kDa (显示 RPSA 蛋白)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (显示 CYBB 蛋白)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (显示 SLC2A4 蛋白)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (显示 ROS1 蛋白) from NADPH oxidase (显示 NOX1 蛋白) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (显示 PKCd 蛋白)- and ERK (显示 EPHB2 蛋白)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)