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Modulates arousal and anxiety. 再加上，我们可以发 和 NPS 蛋白 (5)和数多这个蛋白质的别的产品。
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A SNP within the neuropeptide s gene is associated with decreased bioactivity.
NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR (显示 NPSR1 ELISA试剂盒) activation.
The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR (显示 NPSR1 ELISA试剂盒) system, is summarized.
NPS-NPSR1 (显示 NPSR1 ELISA试剂盒) signaling is likely involved in anxiety
NPS has a novel role in the stimulation of the hypothalamo-pituitary-adrenal axis
the C-terminal region of neuropeptide S maintains importance for in vivo activity
the key residues of NPS involved in NPSR (显示 NPSR1 ELISA试剂盒) activation and suggest a molecular basis for the functional effects of the N107I mutation and for its putative pathophysiological link with asthma
Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 (显示 MMP10 ELISA试剂盒) and TIMP3 (显示 TIMP3 ELISA试剂盒) by NPS-NPSR1 (显示 NPSR1 ELISA试剂盒) signaling may be of relevance in the pathogenesis of asthma.
NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis.
Study showed that the actions of neuropeptide S influenced the excitability of dorsal raphe and laterodorsal tegmentum neurons, which could play a role in the anxiolytic and arousal-promoting effects of this peptide.
NPS-/- mice display significant deficits in exploratory activity, long-term memory and arousal.
Findings demonstrate that neuropeptide S, via selective activation of the neurons bearing neuropeptide S receptor (显示 NPSR1 ELISA试剂盒) in the subiculum complex, ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 in mice.
these results indicate that NPS-NPSR system may regulate locomotion together with the CRF1 system in SN.
Study demonstrated that NPS produces anti-aggressive effects in mice through the selective activation of NPSR (显示 NPSR1 ELISA试剂盒) and that the endogenous NPS/NPSR (显示 NPSR1 ELISA试剂盒) system can exert a role in the control of aggressiveness levels under the present experimental conditions
These data provide evidence for a direct interaction between the corticotropin-releasing factor (显示 CRH ELISA试剂盒) and the NPS system and thereby extend previous observations of NPS-modulated stress responsiveness towards a mechanistic level.
Neuropeptide S knock-out mice display deficits in inhibitory avoidance memory indicating involvement in central noradrenergic systems.
Results describe the neuroanatomical, molecular, and functional aspects of neuropeptide S-producing neurons in the mouse brain.
These data demonstrate that the distribution pattern of the central neuropeptide S system is only partially conserved between mice and rats.
results demonstrate that neuropeptide S and NPSR1 (显示 NPSR1 ELISA试剂盒) regulate respiratory function through a central nervous system-mediated pathway
Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity).
, neuropeptide S