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NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. 再加上，我们可以发NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) 抗体 (107) 和 NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) 蛋白 (5)和数多这个蛋白质的别的产品。
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These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.
Data suggest that histone deacetylase (显示 HDAC1 ELISA试剂盒) inhibitors inhibit the induction of NGF1A-binding protein (显示 NAB1 ELISA试剂盒) Nab2 by brain derived neurotrophic factor (BDNF (显示 BDNF ELISA试剂盒)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32 (显示 PPP1R1B ELISA试剂盒)).
Nab2 is a novel endogenous negative regulator of Egr-1 (显示 EGR1 ELISA试剂盒)-dependent TGF-beta (显示 TGFB1 ELISA试剂盒) signaling responsible for setting the intensity of fibrotic responses
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4 (显示 CHD4 ELISA试剂盒)) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex
NAB2 enhances IL-2 (显示 IL2 ELISA试剂盒) transcription by acting as a coactivator for Egr-1 (显示 EGR1 ELISA试剂盒).NAB2 is recruited to the Egr-1 (显示 EGR1 ELISA试剂盒) binding site of the IL-2 (显示 IL2 ELISA试剂盒) promoter.
We report here, that FGF23 (显示 FGF23 ELISA试剂盒) induces not only Egr-1 (显示 EGR1 ELISA试剂盒) but also two isoforms of NAB2, which are specific co-repressors of Egr-1 (显示 EGR1 ELISA试剂盒).
Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion genes ,the molecular hallmark of solitary fibrous tumours.
Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 (显示 STAT6 ELISA试剂盒) gene fusion as was nonmeningeal solitary fibrous tumor
The detection of nuclear relocation of STAT6 (显示 STAT6 ELISA试剂盒) with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion and helps to discriminate SFTs from histological mimics.
Variants of the NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion gene are found in solitary fibrous tumors of the meninges.
NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.
the majority of intrathoracic SFTs exhibited STAT6 (显示 STAT6 ELISA试剂盒) nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion in glioblastoma.
We delineate the common and rare NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion variants in solitary fibrous tumors
This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 (显示 STAT6 ELISA试剂盒) nuclear expression and NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion similar to their soft tissue counterparts.
This study validated the existence of the NAB2-STAT6 (显示 STAT6 ELISA试剂盒) fusion gene in solitary fibrous tumors and examined its relation with pathological features.
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NGFI-A binding protein 2 (EGR1 binding protein 2)
, EGR-1-binding protein 2
, NGFI-A binding protein 2 (EGR-1 binding protein 2)
, NGFI-A-binding protein 2
, EGR1 binding protein 2
, melanoma-associated delayed early response protein