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Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. 再加上，我们可以发Myoferlin 抗体 (21) 和 和数多这个蛋白质的别的产品。
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Myoferlin is a general component of cancer cell derived exosomes from different breast and pancreatic cancer cell lines.
the cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported.
A novel regulator, myoferlin, of ADAM12 (显示 ADAM12 ELISA试剂盒) is discovered in HeLa cells and this protein increases ADAM12 (显示 ADAM12 ELISA试剂盒) expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin (显示 CDH1 ELISA试剂盒), which plays important roles in the regulation of cell adhesion and tumor metastasis.
Data show myoferlin depletion did not affect STAT3 (显示 STAT3 ELISA试剂盒) transcription factor (STAT3 (显示 STAT3 ELISA试剂盒)) phosphorylation, but completely blocked STAT3 (显示 STAT3 ELISA试剂盒) translocation to nucleus.
This study is the first to report robust age associations for DNA methylation in MYOF and DDO (显示 DDO ELISA试剂盒), both of which have plausible functional roles in aging
Results demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients.
Myoferlin plays a key role in VEGFA (显示 VEGFA ELISA试剂盒) secretion and impacts tumor-associated angiogenesis in human pancreas cancer.
MYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells.
These data provide the first evidence of myoferlin expression in solid human and mouse tumors.
Data indicate that dysferlin (显示 DYSF ELISA试剂盒), otoferlin, and myoferlin do not merely passively adsorb to membranes but actively sculpt lipid bilayers.
these findings demonstrate the importance of dysferlin (显示 DYSF ELISA试剂盒) and myoferlin for transverse tubule function and in the genesis of muscular dystrophy.
Myoferlin gene knockdown not only decreases lipid vesicle fusion in EC but also attenuates Vascular Endothelial Growth Factor (VEGF (显示 VEGF ELISA试剂盒)) Receptor-2 (VEGFR-2) expression.
IGF1 (显示 IGF1 ELISA试剂盒) receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1 (显示 IGF1 ELISA试剂盒)
Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)
myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes.
myoferlin forms a complex with dynamin-2 (显示 DNM2 ELISA试剂盒) and VEGFR-2 (显示 KDR ELISA试剂盒), which prevents CBL (显示 CBL ELISA试剂盒)-dependent VEGFR-2 (显示 KDR ELISA试剂盒) polyubiquitination and proteasomal degradation.
interaction of myoferlin with EHD2 identifies molecular overlap between the endocytic recycling pathway and the machinery that regulates myoblast membrane fusion
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.
fer-1-like 3, myoferlin
, fer-1-like protein 3
, Fer-1-like protein 3