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The protein encoded by MFN1 is a mediator of mitochondrial fusion. 再加上，我们可以发Mitofusin 1 抗体 (139) 和 Mitofusin 1 蛋白 (11)和数多这个蛋白质的别的产品。
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The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.
Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion.
SLC25A46 is a new component in mitochondrial dynamics that serves as a regulator for MFN1/2 oligomerization.
MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.
crystal structures of engineered human MFN1 containing the GTPase (显示 RACGAP1 ELISA试剂盒) domain and a helical domain during different stages of GTP (显示 AK3 ELISA试剂盒) hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin (显示 MFN2 ELISA试剂盒)-related human neuromuscular disorders
These results suggest that MFN (显示 TLL1 ELISA试剂盒) tethers apposing membranes, likely through nucleotide-dependent dimerization.
Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 (显示 DNM1L ELISA试剂盒) during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.
A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1.
miR (显示 MLXIP ELISA试剂盒)-19b targets 3'UTR (显示 UTS2R ELISA试剂盒) sequences of Mfn1 genes inhibit the expression of Mfn1
In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.
A novel role for the endoplasmic reticulum-associated Gp78 (显示 AMFR ELISA试剂盒) ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.
data posit MFN1-mediated mitochondrial dynamics in POMC (显示 POMC ELISA试剂盒) neurons as an intrinsic nutrient-sensing mechanism and unveil an unrecognized link between this subset of neurons and insulin (显示 INS ELISA试剂盒) release.
These results highlight the crucial role of MFN1 in maintaining the competency of the STING pathway.
Despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 (显示 MFN2 ELISA试剂盒) are protected against acute myocardial infarction due to impaired mitochondria/sarcoplasmic reticulum tethering.
We found that mouse embryonic fibroblasts lacking Mfn2 (显示 MFN2 ELISA试剂盒) have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 (显示 MFN2 ELISA试剂盒) does not have a role in adipocyte differentiation.
MFN1 deficiency leads to defects in mitochondrial activity and male infertility.
Report exposes a novel role for Shh (显示 SHH ELISA试剂盒) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.
Ablating Mfn1 eliminates the cardiac-related lethality of Mff knockout mice.
Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2 (显示 MFN2 ELISA试剂盒), OPA1 (optic atrophy 1 protein), and Drp1 (dynamin 1-like protein (显示 DNM1L ELISA试剂盒)). [REVIEW]
Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6 (显示 HDAC6 ELISA试剂盒).
These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 (显示 MFN2 ELISA试剂盒) caused by excessive intracellular Abeta (显示 APP ELISA试剂盒) is the possible molecular mechanism.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
, mitofusin 2
, fzo homolog
, mitochondrial transmembrane GTPase FZO-2
, mitochondrial transmembrane GTPase Fzo-1
, putative transmembrane GTPase
, transmembrane GTPase MFN1
, mitochondrial transmembrane GTPase FZO1B