anti-Meis Homeobox 2 (MEIS2) 抗体

MEIS2 encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. 再加上,我们可以发MEIS2 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MEIS2 4212 O14770
MEIS2 17536 P97367
MEIS2 311311  
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antibodies-online.cn销售最多的anti-MEIS2 抗体

Showing 10 out of 94 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-MEIS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-MEIS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  MCF7 cell lysate Host:  Rabbit  Target Name:  MEIS2  Sample Type:  Human Fetal Brain  Antibody Dilution:  1.0ug/ml 100 μL 2至3个工作日
Cow 非结合性 IHC, WB Human kidney WB Suggested Anti-MEIS2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL 2至3个工作日
小鼠 山羊 非结合性 ELISA, WB   100 μg 6至7个工作日
山羊 非结合性 ELISA, WB 0.1 mg 2至3个工作日
小鼠 非结合性 ELISA, IF, IHC, IHC (p), WB 100 μg 11至14个工作日
Bat 非结合性 IHC, IHC (p), WB 100 μL 11至14个工作日
Bat 山羊 非结合性 ELISA, WB 100 μg 11至14个工作日
小鼠 非结合性 IF, IHC (p), ELISA, WB Immunofluorescence of monoclonal antibody to MEIS2 on HeLa cell. (antibody concentration 10 ᄉg/mL) Immunoperoxidase of monoclonal antibody to MEIS2 on formalin-fixed paraffin-embedded human spleen tissue. [antibody concentration 1 ug/ml] 100 μg 11至12个工作日
Bat 非结合性 WB 100 μL 11至14个工作日

引用最多的anti-MEIS2 抗体

  1. Human Monoclonal MEIS2 Primary Antibody for IF, IHC (p) - ABIN561794 : García-Moreno, Pedraza, Di Giovannantonio, Di Salvio, López-Mascaraque, Simeone, De Carlos: A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. in Nature neuroscience 2010 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal MEIS2 Primary Antibody for IHC, WB - ABIN2775951 : Yang, Hwang, DSouza, Lee, Junn, Mouradian: Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MEIS2 Primary Antibody for ELISA, WB - ABIN4333476 : Mercader, Leonardo, Azpiazu, Serrano, Morata, Martínez, Torres: Conserved regulation of proximodistal limb axis development by Meis1/Hth. in Nature 1999 (PubMed)

  4. Human Polyclonal MEIS2 Primary Antibody for ICC, IF - ABIN4333477 : He, Ebarasi, Zhao, Guo, Ojala, Hultenby, De Val, Betsholtz, Tryggvason: Lmx1b and FoxC combinatorially regulate podocin expression in podocytes. in Journal of the American Society of Nephrology : JASN 2014 (PubMed)


Human Meis Homeobox 2 (MEIS2) interaction partners

  1. Study demonstrated that MEIS2 acted as a promoter of metastasis in colorectal cancer (CRC). Knockdown of MEIS2 significantly suppressed CRC migration, invasion and EMT. MEIS2 was associated with a shorter overall survival time for patients with CRC. These results suggest that MEIS2 may serve as a novel biomarker for CRC.

  2. These data implicate a functional role for MEIS proteins in regulating cancer progression, and support a hypothesis whereby tumor expression of MEIS1 and MEIS2 expression confers a more indolent prostate cancer phenotype, with a decreased propensity for metastatic progression

  3. The present study indicated that Meis2 repress the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 signaling pathway.

  4. these are the first described de novo missense variants in MEIS2, expanding the known mutation spectrum of the newly recognized human disorder caused by aberrations in this gene.

  5. Moderate elevation of MEIS2A expression reduced proliferation of MYCN-amplified human neuroblastoma cells, induced neuronal differentiation and impaired the ability of these cells to form tumors in mice

  6. Loss-of-function MEIS2 mutations were identified in nine patients with palatal defects, congenital heart defects, and intellectual disability.

  7. TAL1 acts as a downstream gene mediating the function of MEIS2 during early hematopoiesis.

  8. Mechanistic analyses integrate this unrecognized anti-atrial function of ISL1 with known and newly identified atrial inducers. In this revised view, ISL1 is antagonized by retinoic acid signaling via a novel player, MEIS2.

  9. High expression of MEIS2 impairs repressive DNA binding of AML1-ETO, inducing increased expression of genes such as the druggable proto-oncogene YES1.

  10. we have identified a novel nonsense MEIS2 mutation in a female patient with cleft palate, cardiac septal defect, severe ID, developmental delay and feeding difficulty with gastro-esophageal reflux. Our findings strongly suggest neurocristopathy be included in the clinical features associated with MEIS2 alterations.

  11. Meis2 as the target of miR-134 in the regulation of cardiomyocyte progenitor cell proliferation.

  12. This is the first report showing a de novo small intragenic mutation in MEIS2 and further confirms the important role of this gene in normal development.

  13. Our results show that MEIS2 is a gene needed for palate closure. In syndromic cases of cleft palate, MEIS2 should be considered among the candidate genes, for example, in cases without 22q11.2 deletions.

  14. FOXM1 is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes.

  15. The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1.

  16. Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes.

  17. The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004).

  18. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.

  19. Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are expressed during early fetal brain development in humans.

  20. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.

Mouse (Murine) Meis Homeobox 2 (MEIS2) interaction partners

  1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation.

  2. a previously unknown link between PcG proteins and downregulation of RA-related signals to mediate the phase transition of Meis2 transcriptional status during forelimb patterning, is reported.

  3. Study identifies Meis2 as a subclass-specific marker for 5-HT3AR-containing interstitial interneurons and demonstrates that the transcriptional and anatomical parcellation of cortical interneurons is developmentally coupled.

  4. identified Meis2 as critical to MN1-induced leukemia, with essential roles in proliferation, self-renewal, impairment of differentiation and disease progression in vitro and in vivo.

  5. MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber.

  6. An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer.

  7. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.

  8. We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer.

  9. we show that simultaneous deletion of Meis1 and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 deficient embryos Pax6 expression is absent

  10. Meis2-null mice are embryonic lethal. The results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse.

  11. Data suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry.

  12. Interaction of Meis2 promoter with midbrain enhancer depends on RING1.

  13. Meis2 cooperates with Pax6 in generic neurogenesis and dopaminergic fate specification in the adult subventricular zone-olfactory bulb system.

  14. The mRNA level of this protein was elevated in limb buds after treatment with retinoic acid.

  15. These data identify Meis2 as a marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during AM cell differentiation.

  16. Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2.

MEIS2 抗原简介


This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Gene names and symbols associated with anti-Meis Homeobox 2 (MEIS2) 抗体

  • Meis homeobox 2 (MEIS2) 抗体
  • Meis homeobox 2 (Meis2) 抗体
  • Meis homeobox 2 L homeolog (meis2.L) 抗体
  • Meis homeobox 2 (meis2) 抗体
  • Meis homeobox 2b (meis2b) 抗体
  • A430109D20Rik 抗体
  • DKFZp469A1832 抗体
  • hst18361 抗体
  • meis2 抗体
  • meis2.1 抗体
  • Meis2a.1 抗体
  • Meis2a.2 抗体
  • mrg1 抗体
  • Stra10 抗体

Protein level used designations for anti-Meis Homeobox 2 (MEIS2) 抗体

Meis homolog 2 , Meis1, myeloid ecotropic viral integration site 1 homolog 2 , Meis1-related gene 1 , TALE homeobox protein Meis2 , homeobox protein Meis2 , meis1-related protein 1 , Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 , myeloid ecotropic viral integration site-related gene 1 , homeoprotein Meis2a.1 , homeoprotein Meis2a.2 , myeloid ecotropic viral insertion site-2a protein , XMeis1-3 protein , Meis homeobox 2 , homeobox protein Meis2-like , myeloid ecotropic viral integration site 2.1

4212 Homo sapiens
17536 Mus musculus
311311 Rattus norvegicus
395588 Gallus gallus
398167 Xenopus laevis
453312 Pan troglodytes
539573 Bos taurus
612759 Canis lupus familiaris
699748 Macaca mulatta
100027000 Monodelphis domestica
100036664 Xenopus (Silurana) tropicalis
100057556 Equus caballus
100174200 Pongo abelii
100392593 Callithrix jacchus
100470022 Ailuropoda melanoleuca
100512756 Sus scrofa
100581076 Nomascus leucogenys
30066 Danio rerio
100732873 Cavia porcellus
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