anti-Major Vault Protein (MVP) 抗体

MVP encodes the major component of the vault complex. 再加上,我们可以发Major Vault Protein 试剂盒 (35)Major Vault Protein 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MVP 9961 Q14764
MVP 64681 Q62667
MVP 78388  
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antibodies-online.cn销售最多的anti-Major Vault Protein 抗体

Showing 10 out of 221 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-MVP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL 2至3个工作日
$289.00
详细
非结合性 EIA, WB 0.4 mL 6至8个工作日
$484.00
详细
非结合性 ELISA, FACS, ICC, IHC, WB Western blot analysis of MVP using anti-MVP antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human placenta tissue lysates, Lane 2: human HepG2 whole cell lysates,  Lane 3: human A549 whole cell lysates,  Lane 4: human PANC-1 whole cell lysates,  Lane 5: human SGC-7901 whole cell lysates,  Lane 6: human MDA-MB-231 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MVP antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MVP at approximately 99KD. The expected band size for MVP is at 99KD. Western blot analysis of MVP using anti-MVP antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat spleen tissue lysates, Lane 2: rat lung tissue lysates, Lane 3: rat kidney tissue lysates, Lane 4: mouse spleen tissue lysates, Lane 5: mouse lung tissue lysates, Lane 6: mouse kidney tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MVP antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MVP at approximately 99KD. The expected band size for MVP is at 99KD. 100 μg 4至6个工作日
$280.00
详细
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells; Lane3: Human Lung Tissue. 100 μg 13至16个工作日
$332.00
详细
非结合性 ELISA, IHC, WB Western blot analysis of Hela whole cell lysates, using MVP Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276995 at 1/100 staining Rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11至12个工作日
$390.77
详细
非结合性 IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE LRP(MVP) antibody antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric , using MVP/LRP, antibody at 1:100 dilution. 100 μL 3至4个工作日
$466.18
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti LRP/MVP Polyclonal Antibody, Unconjugated (ABIN671586) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti LRP/MVP Polyclonal Antibody, Unconjugated (ABIN671586) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日
$329.45
详细
非结合性 IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using MVP antibody (ABIN5971029) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human esophagus using MVP Antibody (ABIN5971029) at dilution of 1/100 (40x lens). 100 μL 11至16个工作日
$426.40
详细
非结合性 IF, IHC, WB Western blot analysis of extracts of various cell lines, using MVP antibody. Immunohistochemistry of paraffin-embedded human kidney cancer using MVP Antibody. 200 μL 12至14个工作日
$438.90
详细
小鼠 PerCP FACS, IF 250 μL 3至4个工作日
$441.85
详细

引用最多的anti-Major Vault Protein 抗体

  1. Human Polyclonal MVP Primary Antibody for ELISA, WB - ABIN545724 : Aronica, Gorter, van Vliet, Spliet, van Veelen, van Rijen, Leenstra, Ramkema, Scheffer, Scheper, Sisodiya, Troost: Overexpression of the human major vault protein in gangliogliomas. in Epilepsia 2003 (PubMed)
    Show all 3 Pubmed References

  2. Fish Polyclonal MVP Primary Antibody for IF (p), IHC (p) - ABIN671586 : Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal MVP Primary Antibody for IF, IHC (p) - ABIN564285 : Rahimi, Wilson, Saylor, Stelow, Thomas, Reibel, Levine, Shonka, Jameson, Read: p16, Cyclin D1, and HIF-1? Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. in International journal of otolaryngology 2012 (PubMed)

  4. Human Polyclonal MVP Primary Antibody for ELISA, IHC - ABIN6263445 : Zhou, Lin, Zhang, Zhang, Zhang, Zhang, Xie, Ren: miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. in Cell proliferation 2017 (PubMed)

更多抗Major Vault Protein的相互作用对抗体

Human Major Vault Protein (MVP) interaction partners

  1. Study found that MVP expression was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues. Higher MVP expression was correlated with better clinical outcomes in patients with lung cancer. Further findings demonstrate that MVP may act as a lung tumor suppressor via inhibiting STAT3 pathway.

  2. Study shows that adipocytes induce major vault protein (MVP)-related multidrug-resistant phenotype in breast cancer cells, which could contribute to obesity-related chemoresistance. In a series of human breast tumors, a gradient of MVP expression was observed, and it was higher at the invasive front, where tumor cells are at close proximity to adipocytes, highlighting the clinical relevance of these results.

  3. Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Up-regulation of MVP expression in macrophages of visceral adipose tissues was correlated with obesity in both humans and mice, suggesting that MVP be involved in obesity-associated inflammation.Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases.

  4. B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhancing B-RAF and MEK interaction. B7-H3 expression increases stem cell population by binding to MVP which regulates the activation of the MAPK kinase pathway. Depletion of MVP blocks the activation of MEK induced by B7-H3 and dramatically inhibits B7-H3 induced stem cells.

  5. KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth.

  6. Knockout of MVP leads to miR-193a accumulation in the exosomal donor cells instead of exosomes, inhibiting tumour progression.

  7. The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant.

  8. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane

  9. Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity

  10. involved in doxorubicin resistance of non-small cell lung cancer

  11. Study found significant upregulation of MVP and BCRP whereas MRP1 and UGT1A4 were unaltered in drug resistant epilepsy brains. While upregulation of BCRP was significantly higher in mesial temporal lobe epilepsy (9.34+/-0.45; p<0.05), upregulation of MVP was significantly higher in focal cortical dysplasia (2.94+/-0.65; p<0.01).

  12. Taxus chinensis var.-mediated downregulation of MRP1, MDR1, and LRP might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.

  13. We believe that for the first time, genetic variants at XRCC6 and MVP genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer

  14. MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population.

  15. NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily.

  16. The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma.

  17. Bag3-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer

  18. LDL increases ABCB1, ABCC1, and LRP expression in a human doxorubicin-resistant uterine sarcoma cell line.

  19. Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR/PI3K-mediated migration and survival pathways in human glioblastoma.

  20. USF1 binding to an E-box element may be critical for basal MVP promoter activation.

Mouse (Murine) Major Vault Protein (MVP) interaction partners

  1. Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis in mice. Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases.

  2. plays major role in anti-viral immunity

  3. MVP may fine-tune SR-A activity in macrophages which contributes to the development of atherosclerosis

  4. MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.

  5. These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling.

  6. Results suggest that major vault protein functions as a novel scaffold protein for both SHP-2 and Erk.

  7. results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection

  8. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH.

Zebrafish Major Vault Protein (MVP) interaction partners

  1. MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.

Purple Sea Urchin (Strongylocentrotus purpuratus) Major Vault Protein (MVP) interaction partners

  1. structure and cellular localization during embryonic development; findings indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea urchin embryogenesis

Major Vault Protein (MVP) 抗原简介

蛋白简介

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with anti-Major Vault Protein (MVP) 抗体

  • major vault protein (MVP) 抗体
  • major vault protein (Mvp) 抗体
  • major vault protein (mvp) 抗体
  • major vault protein L homeolog (mvp.L) 抗体
  • major vault protein (Tc00.1047053510353.10) 抗体
  • major vault protein (Tb927.5.4460) 抗体
  • major vault protein (Tb10.70.0520) 抗体
  • major vault protein (Tb10.70.5840) 抗体
  • putative major vault protein (LMJF_05_0060) 抗体
  • 2310009M24Rik 抗体
  • cb771 抗体
  • LRP 抗体
  • MGC145641 抗体
  • mvp 抗体
  • Tb05.45E22.810 抗体
  • VAULT1 抗体
  • wu:fb52b05 抗体
  • wu:fc02g01 抗体

Protein level used designations for anti-Major Vault Protein (MVP) 抗体

lung resistance-related protein , major vault protein , lung resistance-associated protein

GENE ID SPECIES
9961 Homo sapiens
64681 Rattus norvegicus
78388 Mus musculus
373081 Danio rerio
379630 Xenopus laevis
420049 Gallus gallus
516456 Bos taurus
575735 Strongylocentrotus purpuratus
779746 Xenopus (Silurana) tropicalis
3535684 Trypanosoma cruzi strain CL Brener
3657553 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3662971 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3663013 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5648865 Leishmania major strain Friedlin
100380384 Salmo salar
100622738 Sus scrofa
100726794 Cavia porcellus
100340748 Oryctolagus cuniculus
479783 Canis lupus familiaris
101119435 Ovis aries
100172829 Pongo abelii
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