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Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. 再加上，我们可以发MAEL 蛋白 (6) 和 MAEL 试剂盒 (4)和数多这个蛋白质的别的产品。
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Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence.
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR (显示 MLXIP 抗体)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1 (显示 MTSS1 抗体).
Study demonstrated that MAEL interacts with Snail (显示 SNAI1 抗体) and inhibit E-cadherin (显示 CDH1 抗体) promoter activity. MAEL is an oncogene (显示 RAB1A 抗体) that plays an important role in the development and progression of colon cancer.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (显示 PABPC1 抗体) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (显示 FBN1 抗体).
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (显示 AKT1 抗体)/GSK-3beta/Snail (显示 SNAI1 抗体) signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (显示 HELLS 抗体).
MAEL HMG (显示 SSRP1 抗体)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (显示 TES 抗体)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
cancer/testis antigen 128
, maelstrom homolog
, protein maelstrom homolog
, spermatogenesis associated 35