anti-MYC Binding Protein 2 (MYCBP2) 抗体

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

列出全部抗体 基因 基因ID UniProt
MYCBP2 105689 Q7TPH6
MYCBP2 23077 O75592
MYCBP2    
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产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-MYCBP2 Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-MYCBP2 Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary and DAPI staining 100 μL 3至7个工作日
$327.80
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Alexa Fluor 594 IF (p)   100 μL 14至21个工作日
$430.10
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Cy3 IF (p)   100 μL 14至21个工作日
$430.10
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Cy5 IF (p)   100 μL 14至21个工作日
$430.10
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Cy5.5 IF (p)   100 μL 14至21个工作日
$430.10
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Cy7 IF (p)   100 μL 14至21个工作日
$430.10
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HRP IHC (p)   100 μL 14至21个工作日
$430.10
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Alexa Fluor 350 IF (p)   100 μL 14至21个工作日
$430.10
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Alexa Fluor 488 IF (p)   100 μL 14至21个工作日
$430.10
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Alexa Fluor 555 IF (p)   100 μL 14至21个工作日
$430.10
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更多抗MYCBP2的相互作用对抗体

Mouse (Murine) MYC Binding Protein 2 (MYCBP2) interaction partners

  1. this study shows that Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice

  2. nuclear localization of Ran was strongly increased in MYCBP2-deficient DRGs

  3. Arf-bp1 and Pam are novel regulators of circadian gene expression that target Rev-erb alpha for degradation

  4. Mycbp2 and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance

  5. Phr1 is identified as a key regulator of a core axon degeneration program that balances axon survival and loss in various neuronal cell types.

  6. The ubiquitin ligase complex containing Pam-Fbxo45 likely targets additional synaptic and axonal proteins, which may explain the overlapping neurodevelopmental defects observed in Phr1 and Fbxo45 deficiency.

  7. These results show that Phr1 is an essential regulator of retinal ganglion cell projection during both dLGN and SC topographic map development.

  8. p38 MAPK activation can inhibit activity-induced ion channel internalization and MYCBP2 regulates internalization of TRPV1 in peripheral sensory neurons as well as duration of thermal hyperalgesia through p38 MAPK

  9. Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands.

  10. Phr1 is required for formation of major CNS axon tracts via a mechanism that is both cell-nonautonomous and independent of DLK.

  11. Thus, efficacious pathfinding requires Phr1 activity for coordinating the cytoskeletal organization that distinguishes axons from growth cones.

  12. Protein Associated with Myc (PAM) was identified as a binding partner of KCC2.

  13. Results show that a loss-of-function allele of Phr1 resulting in respiratory distress at birth.

Human MYC Binding Protein 2 (MYCBP2) interaction partners

  1. MYCBP2, a member of the c-myc oncogene family, is a direct functional target of miR-1247. Furthermore, in colorectal cancer patients, MYCBP2 protein levels are associated with miR-1247 levels and survival

  2. identification of the neuron-associated E3 ligase MYCBP2 (also known as PHR1) as the apparent single member of a class of RING-linked E3 ligase with esterification activity and intrinsic selectivity for threonine over serine

  3. Data indicate an oncogenic role for an Ikaros protein/MYCBP2 protein/proto-oncogene protein c-MYC axis in adult acute lymphoblastic leukemia (ALL), providing a mechanism of target therapies that activate Ikaros in ALL.

  4. Arf-bp1 and Pam are novel regulators of circadian gene expression that target Rev-erb alpha for degradation

  5. Data show that epithelial-mesenchymal transition (EMT)-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45).

  6. In castration resistant prostate cancer, MYCBP2 is down-regulated at the mRNA and protein levels.

  7. We describe a distinct excavated optic disc anomaly associated with high myopia and increased axial length. The condition appears to follow an autosomal dominant pattern and segregate with a deletion in MYCBP2.

  8. Pam, through its interaction with tuberin, could regulate the ubiquitination and proteasomal degradation of the tuberin-hamartin complex particularly in the CNS

  9. PAM the longest lasting nontranscriptional regulator of adenylyl cyclase activity known to date and presents a novel mechanism for the temporal regulation of cAMP signaling

  10. Identifies the region in PAM that inhibits the domain of type V adenylyl cyclase.

  11. PAM protein activated by facilitating the GDP/GTP-exchange of RHEBL1 protein which is an activator of mTOR protein.

MYCBP2 抗原简介

蛋白简介

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.

Gene names and symbols associated with MYCBP2

  • MYC binding protein 2 (Mycbp2) 抗体
  • MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2) 抗体
  • AU023734 抗体
  • AW107953 抗体
  • AW546647 抗体
  • C130061D10Rik 抗体
  • PAM 抗体
  • Phr1 抗体
  • R75243 抗体

Protein level used designations for MYCBP2

Myc-binding protein 2 , pam, highwire, rpm 1 , pam/highwire/rpm-1 protein , probable E3 ubiquitin-protein ligase MYCBP2 , protein associated with Myc , myc-binding protein 2

GENE ID SPECIES
105689 Mus musculus
23077 Homo sapiens
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