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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上，我们可以发MDS1 and EVI1 Complex Locus 抗体 (117) 和 MDS1 and EVI1 Complex Locus 蛋白 (8)和数多这个蛋白质的别的产品。
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Letter/Case Report: ETV6 (显示 ETV6 ELISA试剂盒)/MECOM gene fusion in therapy-related acute myeloid leukemia (显示 BCL11A ELISA试剂盒) with t(3;12) and monosomy 7.
These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs
Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (显示 ETS1 ELISA试剂盒)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis
The expression of EVI1 and SOX9 (显示 SOX9 ELISA试剂盒) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (显示 FRAP1 ELISA试剂盒) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (显示 FRAP1 ELISA试剂盒) targeting failure
EVI1 contributes to PCa (显示 FLVCR1 ELISA试剂盒) progression by regulating different oncogenic functions. EVI1 regulates the PCa (显示 FLVCR1 ELISA试剂盒) stem cell compartment responsible for disease initiation and also development of CRPC.
oncogenic potential for EVI1 in modulating genomic stability
EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.
EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (显示 CKMT1B ELISA试剂盒) expression by repressing the myeloid differentiation regulator RUNX1 (显示 RUNX1 ELISA试剂盒).
EVI1 transcription is directly regulated by LEF1 (显示 LEF1 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) complex in myeloid blast crisis of chronic myeloid leukemia (显示 BCL11A ELISA试剂盒). Loss of p53 (显示 TP53 ELISA试剂盒) function as a key regulator for beta-catenin (显示 CTNNB1 ELISA试剂盒)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (显示 BCL11A ELISA试剂盒).
we demonstrated that miR (显示 MLXIP ELISA试剂盒)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (显示 MLXIP ELISA试剂盒)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (显示 MLXIP ELISA试剂盒)-22-mediated MECOM degradation increased c-Jun (显示 JUN ELISA试剂盒) but decreased GATA2 (显示 GATA2 ELISA试剂盒) expression, which results in increased interaction between c-Jun (显示 JUN ELISA试剂盒) and PU.1
Gata2 (显示 GATA2 ELISA试剂盒) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice
the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA ELISA试剂盒) from EVI1-induced suppression.
Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 ELISA试剂盒), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 ELISA试剂盒) levels.
Survivin (显示 BIRC5 ELISA试剂盒) partially regulates HSC (显示 FUT1 ELISA试剂盒) function by modulating the Evi-1 transcription factor and its downstream targets
Thrombopoietin (显示 THPO ELISA试剂盒)/MPL (显示 MPL ELISA试剂盒) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Prdm16 (显示 PRDM16 ELISA试剂盒) and Prdm3 control postnatal BAT (显示 BAAT ELISA试剂盒) identity and function.
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL ELISA试剂盒)) fusion protein (MFP) leukemia
nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 ELISA试剂盒) signaling
Prdm3 and prdm16 (显示 PRDM16 ELISA试剂盒) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.
Evi-1 (显示 RUNX1 ELISA试剂盒) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
AML1-EVI-1 fusion protein
, MDS1 and EVI1 complex locus protein EVI1
, MDS1 and EVI1 complex locus protein MDS1
, ecotropic virus integration site 1 protein homolog
, myelodysplasia syndrome-associated protein 1
, oncogene EVI1
, zinc finger protein Evi1
, ecotropic viral integration site 1
, ecotropic virus integration site 1 protein
, myelodysplasia syndrome 1 homolog
, myelodysplasia syndrome 1 protein homolog
, PR domain containing 3
, MDS1 and EVI1 complex locus
, MDS1 and EVI1 complex locus protein EVI1-like
, MDS1 and EVI1 complex locus protein EVI1-A
, ecotropic virus integration site 1 protein homolog-A
, myelodysplasia syndrome 1-ectopic viral integration site 1