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Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. 再加上，我们可以发Lrig1 抗体 (68) 和 Lrig1 蛋白 (11)和数多这个蛋白质的别的产品。
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MiR (显示 MLXIP ELISA试剂盒)-183 overexpression promoted radioresistance of glioblastoma via down-regulating LRIG1 and increasing the activity of EFGR (显示 EGFR ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒).
LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma
LRIG1 expression in human GC tissues is inversely correlated with miR (显示 MLXIP ELISA试剂盒)-20a and EGFR (显示 EGFR ELISA试剂盒).
Role of LRIG1 in cancer [review]
LRIG1 expression may represent a barrier to EMT (显示 ITK ELISA试剂盒)
LRIG1 role in the atrophic epidermis
Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported.
LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs (显示 PASK ELISA试剂盒) via inhibiting PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) and Ras/Raf (显示 RAF1 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒) pathways, and it might be a new target for gene therapy ofPituitary adenomas
LRIG1 and Fascin-1 (显示 FSCN1 ELISA试剂盒) were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
Results suggest that the LRIG1could negatively control MRP-1 (显示 MDM4 ELISA试剂盒) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.
Lrig1 marks gastric corpus epithelial progenitor cells capable of repopulating the damaged oxyntic mucosa by differentiating into normal gastric lineage cells in mouse stomach.
findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (显示 NTRK2 ELISA试剂盒) with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (显示 BDNF ELISA试剂盒) during brain development
LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin
a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (显示 AREG ELISA试剂盒) and Egfr (显示 EGFR ELISA试剂盒) activity.
LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.
Loss of one Apc (显示 APC ELISA试剂盒) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.
At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.
LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (显示 STAT3 ELISA试剂盒).
A review summarizes the data that LRIG1 is a ERBB (显示 EGFR ELISA试剂盒) negative regulator and tumour suppressor.
Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).
leucine-rich repeat protein LRIG1
, leucine-rich repeats and immunoglobulin-like domains protein 1
, ortholog of mouse integral membrane glycoprotein LIG-1
, integral membrane glycoprotein