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Orphan receptor. 再加上，我们可以发LGR5 抗体 (211) 和 LGR5 蛋白 (8)和数多这个蛋白质的别的产品。
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LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.
Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2 (显示 RSPO2 ELISA试剂盒).
Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.
sorted Reg4 (显示 REG4 ELISA试剂盒)(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch (显示 NOTCH1 ELISA试剂盒) inhibition and Wnt (显示 WNT2 ELISA试剂盒) activation
The Lgr5-expressing cells differentiate into hair cells in high yield.
Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5-expressing intestinal stem cells.
Arrb1 (显示 ARRB1 ELISA试剂盒) reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.
demonstrates that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection
Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.
Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.
LGR5 overexpression was associated with high T stage and LN metastasis status in breast cancer. High LGR5 expression was also associated with reduced relapse-free survival, indicating that LGR5 may represent a promising prognostic marker for breast cancer patients.
LGR5 is a critical effector of DDX1 in colorectal cancer cells.
Logarithmic expansion of LGR5-expressing cells was observed in human colorectal cancer.
Findings suggest a tumor suppressor role for miR (显示 MLXIP ELISA试剂盒)-216a in gliomas, which inhibits glioma cell proliferation, migration, and invasion by targeting LGR5.
LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, there were correlations between LGR5 and CRC (显示 CALR ELISA试剂盒)-specific genes, including dickkopf (显示 DKK1 ELISA试剂盒) WNT (显示 WNT2 ELISA试剂盒) signaling pathway inhibitor 4 (DKK4 (显示 DKK4 ELISA试剂盒)) and SPARC-related modular calcium binding 2 (SMOC2 (显示 SMOC2 ELISA试剂盒)
LGR5 expression is transiently upregulated during the early stage of cardiomyocyte differentiation from hPSCs, and although LGR5 expression is not required for maintaining hPSCs in the undifferentiated state, knockdown of LGR5 leads to decreased expression of key cardiac transcription factors at the early stage with eventual lack of robust beating cardiomyocytes at the late stage.
Lgr5 plays important roles in angiogenesis. Lgr5-specific siRNA could be designed into an effective therapeutic agent to inhibit gastric cancer angiogenesis.
A regulatory mechanism of LGR5 expression in gastric carcinogenesis, with SP1 (显示 PSG1 ELISA试剂盒) as an important component of the transcriptional complex and LGR5 activity, which is modulated by its ligands RSPO1 (显示 RSPO1 ELISA试剂盒) and RSPO2 (显示 RSPO2 ELISA试剂盒), whose expression is modulated by methylation.
these results demonstrate that Lgr5 activation of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
leucine-rich repeat-containing G protein-coupled receptor 5
, leucine-rich repeat-containing G-protein coupled receptor 5A
, leucine-rich repeat-containing G-protein coupled receptor 5a
, G protein-coupled receptor 49
, G-protein coupled receptor 49
, follicle expressed hormone
, leucine-rich repeat-containing G-protein coupled receptor 5
, orphan G-protein coupled receptor FEX
, G-protein coupled receptor 67
, G-protein coupled receptor HG38
, orphan G protein-coupled receptor HG38