Laminin, gamma 2 (LAMC2) ELISA试剂盒

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. 再加上,我们可以发LAMC2 抗体 (55)LAMC2 蛋白 (10)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
LAMC2 3918 Q13753
LAMC2 16782  
大鼠 LAMC2 LAMC2 192362  
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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
6.7 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Log in to see 13至16个工作日
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引用最多的LAMC2 ELISA试剂盒

  1. Human LAMC2 ELISA Kit for Sandwich ELISA - ABIN417810 : Kosanam, Prassas, Chrystoja, Soleas, Chan, Dimitromanolakis, Blasutig, Rückert, Gruetzmann, Pilarsky, Maekawa, Brand, Diamandis: Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues. in Molecular & cellular proteomics : MCP 2013 (PubMed)
    Show all 4 Pubmed References

适于 LAMC2 相互作用对的更多 ELISA 试剂盒

Human Laminin, gamma 2 (LAMC2) interaction partners

  1. The results of this study highlight the value of LAMC2 as a marker of cancer invasion. LAMC2-positive foci in leukoplakia suggest an imminent risk of cancer.

  2. Results indicate that LAMC2-Dox mice expressing the human protein are unable to sustain structuring of a proper basement membrane (BM) at the interface between ameloblasts and maturing enamel. This failure may be related to the atypical composition of the BM in the maturation stage and reaffirms that the atypical BM is essential for enamel maturation.

  3. Overexpression of LAMC2 and knockdown of CD82 (显示 CD82 ELISA试剂盒) markedly promoted GC cell invasion and activated EGFR (显示 EGFR ELISA试剂盒)/ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-MMP7 (显示 MMP7 ELISA试剂盒) signaling via upregulation of the expression of phosphorylated (p)-EGFR (显示 EGFR ELISA试剂盒), p-ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and MMP7 (显示 MMP7 ELISA试剂盒).

  4. The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha is present.

  5. Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3 (显示 LAMA3 ELISA试剂盒), 59% carried mutations in both alleles of LAMB3 (显示 LAMB3 ELISA试剂盒), and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3 (显示 LAMA3 ELISA试剂盒), LAMB3 (显示 LAMB3 ELISA试剂盒), or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely

  6. Laminin expression depends on Ecad (显示 CDH1 ELISA试剂盒) loss and allows Ecad (显示 CDH1 ELISA试剂盒)-defective gastric cancer cells to survive and invade.

  7. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (显示 ITK ELISA试剂盒) and may be a potential therapeutic target.

  8. LAMC2 is a novel non-small cell lung cancer prognostic factor.

  9. Diagnostic value of p40 (显示 IL9 ELISA试剂盒) and LN332 in metaplastic spindle cell carcinoma of the breast was found to be less than that of routinely used markers (p63 (显示 RPE65 ELISA试剂盒) and cytokeratins). LN332 showed staining in a significant proportion of phyllodes tumours and sarcomas.

  10. The elevated expression of LAMC2 on cancer cells appears to drive tumorigenesis through its interactions with several cell-surface receptors

Mouse (Murine) Laminin, gamma 2 (LAMC2) interaction partners

  1. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (显示 ITK ELISA试剂盒) and may be a potential therapeutic target.

  2. Periostin (显示 POSTN ELISA试剂盒) was associated with laminin gamma2, and this association enhanced the proteolytic cleavage of the laminin gamma2 long form to produce its short form.

  3. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (显示 NID1 ELISA试剂盒), fibulin-1 (显示 FBLN1 ELISA试剂盒) and fibulin-2 (显示 FBLN2 ELISA试剂盒)

  4. Thymosin beta(4 (显示 TMSB4X ELISA试剂盒)) stimulates Lamc2 production independent of TGF-beta (显示 TGFB1 ELISA试剂盒).

  5. agrin (显示 AGRN ELISA试剂盒) and perlecan (显示 HSPG2 ELISA试剂盒) cluster with laminin-2 to contribute to assembly of aneural AChR clusters that precede neural agrin (显示 AGRN ELISA试剂盒) release as well as affect later NMJ development

  6. Protein production was in excess of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2.

  7. Laminin gamma2 mediates Wnt5a (显示 WNT5A ELISA试剂盒)-induced invasion of gastric cancer cells.

LAMC2 抗原简介

Antigen Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

Gene names and symbols associated with Laminin, gamma 2 (LAMC2) ELISA试剂盒

  • laminin subunit gamma 2 (LAMC2) 抗体
  • laminin, gamma 2 (Lamc2) 抗体
  • laminin subunit gamma 2 (Lamc2) 抗体
  • AA589349 抗体
  • B2T 抗体
  • BM600 抗体
  • CSF 抗体
  • EBR2 抗体
  • EBR2A 抗体
  • LAMB2T 抗体
  • LAMC2 抗体
  • LAMNB2 抗体

Protein level used designations for Laminin, gamma 2 (LAMC2) ELISA试剂盒

laminin 5 gamma 2 subunit , laminin subunit gamma-2 , laminin-5 gamma 2 , laminin, gamma 2 , laminin, gamma 2-like , laminin 5 gamma 2 , BM600-100kDa , CSF 140 kDa subunit , cell-scattering factor 140 kDa subunit , epiligrin subunit gamma , kalinin subunit gamma , ladsin 140 kDa subunit , laminin B2t chain , large adhesive scatter factor 140 kDa subunit , nicein subunit gamma , kalinin/nicein/epiligrin 100 kDa subunit , laminin gamma2 chain , laminin-5 subunit gamma , nicein, 100kD , nicein, 100kDa , lamimin, gamma 2

408043 Gallus gallus
442939 Canis lupus familiaris
457571 Pan troglodytes
511043 Bos taurus
715212 Macaca mulatta
100216328 Ovis aries
3918 Homo sapiens
16782 Mus musculus
791245 Equus caballus
192362 Rattus norvegicus
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