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KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. 再加上，我们可以发Kv Channel Interacting Protein 3, Calsenilin 抗体 (166) 和 Kv Channel Interacting Protein 3, Calsenilin 蛋白 (13)和数多这个蛋白质的别的产品。
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targeting SmgGDS (显示 RAP1GDS1 ELISA试剂盒) induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.
Disruption of DREAM and RB-E2F (显示 E2F1 ELISA试剂盒) complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53 (显示 TP53 ELISA试剂盒)-mediated downregulation of cell cycle genes. [review]
This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2 (显示 CA2 ELISA试剂盒)+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 hand is not capable of binding to Ca(2 (显示 CA2 ELISA试剂盒)+).
Our approach yields high confidence ranked target gene maps for TP53 (显示 TP53 ELISA试剂盒), DREAM, MMB-FOXM1 (显示 FOXM1 ELISA试剂盒) and RB-E2F (显示 E2F1 ELISA试剂盒) and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.
downregulation of these genes through the p53 (显示 TP53 ELISA试剂盒)-p21 (显示 CDKN1A ELISA试剂盒)-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53 (显示 TP53 ELISA试剂盒).
Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.
GCM1-directed villous trophoblast differentiation is repressed by DREAM
p53 (显示 TP53 ELISA试剂盒) can repress transcription of cell cycle genes through a p21(WAF1/CIP1 (显示 CDKN1A ELISA试剂盒))-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.
The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
expression of calsenilin leads to a disruption of presenilin 1 (显示 PSEN1 ELISA试剂盒)/gamma-secretase-mediated epsilon-cleavage of N-cadherin (显示 CDH2 ELISA试剂盒), which results in the significant accumulation of N-cadherin (显示 CDH2 ELISA试剂盒) C-terminal fragment 1
Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L (显示 CTSL1 ELISA试剂盒) and the monoglyceride lipase (显示 MGLL ELISA试剂盒) as two new DREAM transcriptional targets related to pain.
association of PS1 (显示 PSEN1 ELISA试剂盒) carboxyl peptide (residues 445-467, HL9 (显示 DDC ELISA试剂盒)) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 (显示 PSEN1 ELISA试剂盒) and F252 from DREAM.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB (显示 FOSB ELISA试剂盒), phosphoacetylated histone H3 (显示 HIST3H3 ELISA试剂盒), and dynorphin-B in the striatum
NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein and the T1 domain of the Kv4.3 (显示 KCND3 ELISA试剂盒) channels through reorientation of helix 10 on KChIP3
studies define the critical opposing functions of DREAM and USF1 (显示 USF1 ELISA试剂盒) in inhibiting and inducing A20 (显示 TNFAIP3 ELISA试剂盒) expression
Expression of DREAM in neuroblastoma cells enhances cisplatin mediated caspase-3 (显示 CASP3 ELISA试剂盒) activity.
Restoring CANT1 (显示 CANT1 ELISA试剂盒) levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1 (显示 CANT1 ELISA试剂盒), and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
In cardiomyocytes, [Ca2 (显示 CA2 ELISA试剂盒)+]i-activated calmodulin kinase II (CaMKII (显示 CAMK2 ELISA试剂盒)) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c (显示 CACNA1C ELISA试剂盒)).
zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
A-type potassium channel modulatory protein 3
, DRE-antagonist modulator
, calsenilin, presenilin-binding protein, EF hand transcription factor
, kv channel-interacting protein 3
, potassium channel interacting protein 3
, calsenilin, presenilin binding protein, EF hand transcription factor
, A-type potassium channel modulating protein 3
, calsenilin presenilin-binding protein EF hand transcription factor
, calsenilin, presenilin-binding protein, EF hand transcription fa
, downstream regulatory element-antagonist modulator
, Kv channel interacting protein 3, calsenilin