Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) ELISA试剂盒

KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. 再加上,我们可以发Kv Channel Interacting Protein 3, Calsenilin 抗体 (152)Kv Channel Interacting Protein 3, Calsenilin 蛋白 (13)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
KCNIP3 30818 Q9Y2W7
KCNIP3 56461 Q9QXT8
KCNIP3 65199 Q9JM47
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Human Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

  2. targeting SmgGDS induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.

  3. Disruption of DREAM and RB-E2F complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53-mediated downregulation of cell cycle genes. [review]

  4. This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 hand is not capable of binding to Ca(2+).

  5. Our approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.

  6. downregulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53.

  7. The aim of this study was to investigate somatic mutations and DREAM gene expression in human multinodular goiter

  8. Imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex.

  9. Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.

  10. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  11. p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.

  12. Genetic variation in the DREAM pathway genes was associated with the extent of pain reporting in a population-based cohort.

  13. The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

  14. expression of calsenilin leads to a disruption of presenilin 1/gamma-secretase-mediated epsilon-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1

  15. The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130-DREAM complex.

  16. These findings suggest that calsenilin degradation is primarily mediated by the UPP and that impairment in the UPP may contribute to the involvement of calsenilin in disease-associated neurodegeneration.

  17. apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells

  18. Immunoreactivity of calsenilin in the hippocampus derived from an epilepsy patient is significantly decreased compared with normal brain.

  19. calsenilin can be phosphorylated by casein kinase I and that its phosphorylation can be regulated by intracellular calcium.

  20. The level of intracellular calcium can modulate the nuclear translocation of calsenilin and this process does not involve the direct binding of calcium to calsenilin

Mouse (Murine) Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in Huntington mice.

  2. Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L and the monoglyceride lipase as two new DREAM transcriptional targets related to pain.

  3. Our findings demonstrate for the first time that DREAM plays an important role in thrombosis and hemostasis in mice.

  4. association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM.

  5. DREAM plays an important role in structural plasticity in the hippocampus.

  6. Terbium(III) binding preserves the folding state of DREAM with minimal changes to overall structure of DREAM.

  7. Results presented in this study show for the first time that down-regulation of DREAM promotes the degeneration of RGCs, amacrine cells, and bipolar cells.

  8. The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.

  9. The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB, phosphoacetylated histone H3, and dynorphin-B in the striatum

  10. NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein and the T1 domain of the Kv4.3 channels through reorientation of helix 10 on KChIP3

  11. These results provide the first evidence that DR/C/K3 plays a timing-dependent role in estradiol regulation of learning, memory, and plasticity.

  12. studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression

  13. DREAM is a major master switch transcription factor.

  14. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  15. Expression of DREAM in neuroblastoma cells enhances cisplatin mediated caspase-3 activity.

  16. Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation

  17. In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c).

  18. Sumoylation regulates the nuclear localization of DREAM in differentiated neurons.

  19. endogenous BDNF is involved in spinal sensitization following inflammation and blockade of BDNF induction in DREAM transgenic mice underlies the failure to develop spinal sensitization

  20. Results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory.

Zebrafish Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) interaction partners

  1. zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas

Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) 抗原简介

Antigen Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with KCNIP3

  • potassium voltage-gated channel interacting protein 3 (KCNIP3) 抗体
  • Kv channel-interacting protein 4 (LOC5568664) 抗体
  • calsenilin (CpipJ_CPIJ002549) 抗体
  • calsenilin (Tsp_05009) 抗体
  • Kv channel interacting protein 3, calsenilin (Kcnip3) 抗体
  • potassium voltage-gated channel interacting protein 3 (Kcnip3) 抗体
  • Kv channel interacting protein 3b, calsenilin (kcnip3b) 抗体
  • Kv channel interacting protein 3, calsenilin (KCNIP3) 抗体
  • potassium voltage-gated channel interacting protein 3 (kcnip3) 抗体
  • 4933407H12Rik 抗体
  • AI413860 抗体
  • csen 抗体
  • Dream 抗体
  • im:7145308 抗体
  • KChIP3 抗体
  • KCNIP3 抗体
  • R74849 抗体
  • rKChIP3 抗体
  • zgc:73306 抗体

Protein level used designations for KCNIP3

A-type potassium channel modulatory protein 3 , DRE-antagonist modulator , calsenilin , calsenilin, presenilin-binding protein, EF hand transcription factor , kv channel-interacting protein 3 , potassium channel interacting protein 3 , calsenilin, presenilin binding protein, EF hand transcription factor , A-type potassium channel modulating protein 3 , KChIP3 , calsenilin presenilin-binding protein EF hand transcription factor , calsenilin, presenilin-binding protein, EF hand transcription fa , downstream regulatory element-antagonist modulator , Kv channel interacting protein 3, calsenilin

GENE ID SPECIES
30818 Homo sapiens
5568664 Aedes aegypti
6033823 Culex quinquefasciatus
10912880 Trichinella spiralis
56461 Mus musculus
65199 Rattus norvegicus
393755 Danio rerio
459401 Pan troglodytes
513316 Bos taurus
704307 Macaca mulatta
100135241 Xenopus (Silurana) tropicalis
100856050 Canis lupus familiaris
100717101 Cavia porcellus
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