anti-Kinesin Family Member 5A (KIF5A) 抗体

KIF5A encodes a member of the kinesin family of proteins. 再加上,我们可以发Kinesin Family Member 5A 试剂盒 (10)Kinesin Family Member 5A 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
KIF5A 3798 Q12840
KIF5A 16572 P33175
KIF5A 314906 Q6QLM7
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Showing 10 out of 70 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 IHC, WB Rabbit Anti-KIF5A antibody   Paraffin Embedded Tissue: Human Lung cell Cellular Data: bronchiole epithelium of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X WB Suggested Anti-KIF5A Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain 100 μL 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA   100 μg 6至7个工作日
$291.53
详细
非结合性 EIA, IF, IHC (p), WB 50 μg 6至8个工作日
$495.00
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非结合性 IHC, IHC (p), WB 100 μL 11至14个工作日
$551.83
详细
非结合性 IHC, WB Western blot analysis of extracts of various cell lines, using KIF5A antibody (ABIN1873405) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 100 μL 11至13个工作日
$366.77
详细
非结合性 ELISA, ICC, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with KIF5A antibody ABIN343920 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-KIF5A antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg 11至14个工作日
$484.00
详细
非结合性 EIA, IF, WB   0.1 mg 4至8个工作日
$522.50
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非结合性 EIA, IF, WB   0.1 mg 4至8个工作日
$522.50
详细
非结合性 ICC, ELISA, WB 0.1 mg 11至14个工作日
$551.83
详细
非结合性 ICC, ELISA, WB   100 μg 15至19个工作日
$527.03
详细

引用最多的anti-Kinesin Family Member 5A 抗体

  1. Human Polyclonal KIF5A Primary Antibody for ICC, ELISA - ABIN1002705 : Hirokawa: mRNA transport in dendrites: RNA granules, motors, and tracks. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal KIF5A Primary Antibody for ICC, ELISA - ABIN1002704 : Niclas, Navone, Hom-Booher, Vale: Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. in Neuron 1994 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal KIF5A Primary Antibody for IF, WB - ABIN541625 : Fichera, Lo Giudice, Falco, Sturnio, Amata, Calabrese, Bigoni, Calzolari, Neri: Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. in Neurology 2004 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal KIF5A Primary Antibody for ELISA - ABIN546875 : Reid, Kloos, Ashley-Koch, Hughes, Bevan, Svenson, Graham, Gaskell, Dearlove, Pericak-Vance, Rubinsztein, Marchuk: A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). in American journal of human genetics 2002 (PubMed)

更多抗Kinesin Family Member 5A的相互作用对抗体

Zebrafish Kinesin Family Member 5A (KIF5A) interaction partners

  1. Deletion of a kinesin I motor unmasks a mechanism of homeostatic axon-branching control by neurotrophin-3.

  2. Our results shed light on Kinesin complexity and reveal determinants of specific Kif5A functions in mitochondrial transport, adaptor binding, and axonal maintenance.

Human Kinesin Family Member 5A (KIF5A) interaction partners

  1. KIF5A p.Ala361Val cause spastic paraplegia and primary progressive multiple sclerosis.

  2. ALS-associated mutations in KIF5A, are located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases.

  3. This study found that the mutations located specifically in a C-terminal hotspot of KIF5A can cause a classical amyotrophic lateral sclerosis phenotype, and underline the involvement of intracellular transport processes in amyotrophic lateral sclerosis pathogenesis.

  4. These results support our hypothesis that KIF5A is responsible for collagen transportation and secretion from HPMCs.

  5. This study identified three pathogenic KIF5A mutations in Korean Charcot-Marie-Tooth neuropathy type 2 patients by whole exome sequencing. Two mutations (p.Arg204Trp and p.Arg280His) were previously reported, but p.Leu558Pro was determined to be a novel de novo mutation.

  6. We conclude that reduced expression of axonal motor KIF5A may have important implications in determining axonal transport deficits and ongoing neurodegeneration in multiple sclerosis

  7. Kinesin family member 5A protein (Kif5A) with hereditary spastic paraplegia (HSP)-causing mutations showed a variety of significantly reduced catalytic and mechanical activities as a result of each mutation, with the shared phenotype from each that motility was significantly reduced.

  8. Variants in SPAST and KIF5A were the most common causes of autosomal dominant hereditary spastic paraplegia in Greece. The first nonsense mutation in KIF5A was identified in HSP patient.

  9. De novo stop-loss frameshift variants in KIF5A result in a novel phenotype that includes severe infantile onset myoclonus, hypotonia, optic nerve abnormalities, dysphagia, apnea, and early developmental arrest.

  10. KIF5A p.Ser974fs de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.

  11. Zinc ion-mediated inhibition of KIF5A activity might be one molecular cause contributing to impaired transport processes within brain and other organs in cases of zinc dyshomeostasis.

  12. This report describes the first known Asian family with a KIF5A mutation and broadens the clinical and electrophysiological spectrum associated with KIF5A-SPG10 mutations.

  13. study describes 2 Spanish families with an adult onset complicated autosomal dominant hereditary spastic paraplegia with a mild sensory neuropathy; identified 2 novel mutations c.773 C>T and c.833 C>T in the KIF5A gene resulting in the P258L and P278L substitutions; both were located in the highly conserved kinesin motor domain of the protein

  14. Kinesin-14 blocks microtubule nucleation in yeast and reveal that this inhibition is countered by the kinesin-5 protein, Cut7.[Cut7, Pkl1]

  15. the novel mutation p.Leu259Gln in two siblings affected by Hereditary spastic paraplegia (HSP) complicated by deafness and in their father with a pure form of HSP.

  16. Combining next-generation sequencing and conventional sequencing, study confirms that KIF5A mutations can cause variable phenotypes ranging from hereditary spastic paraplegia to Charcot-Marie-Tooth disease type 2

  17. Conformations of microtubule-bound human kinesin-5 motor domain were visualised at successive steps in its ATPase cycle.

  18. A review of the mechanism of pathogenesis involved in spastic paraplegia type 10 when KIF5A is inactivated by mutations.

  19. Data suggest that the impairment of the microtubule-kinesin function by alpha-synuclein oligomers drives early neurite pathology.

  20. This study extends the phenotype of SPG10 and argues for abnormalities in the axonal vesicular transport.

Mouse (Murine) Kinesin Family Member 5A (KIF5A) interaction partners

  1. The authors concluded that kinesin-1 proteins KIF5A, -5B, and -5C are important in the anterograde transport of the majority of herpes simplex virus enveloped virions in neuronal axons and kinesin-3 proteins are less important.

  2. These results support our hypothesis that KIF5A is responsible for collagen transportation and secretion from HPMCs.

  3. Klf5 contributes to adult mouse corneal epithelial homeostasis by promoting (1) permeability barrier function through upregulation of Tjp1, Gkn1, Dsg1a, Lama3, and Lamb1, and (2) basal cell proliferation through upregulation of cyclin-D1 and suppression of phospho(Ser-10) p27/Kip1

  4. Results from the present study reveal a new system mediated by kinesin-1 sorting in axons that differentially controls stability of arbor terminals.

  5. Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity.

  6. KIF5-SNPH interaction mediates activity-induced immobilization of axonal mitochondria.

  7. Found a role of KIF5A in process outgrowth and axonal transport of mitochondria, affecting motor neurons more severely than sensory neurons.

  8. Expression of Kif5a in the mouse prefrontal cortex is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).

  9. Data suggest that kinesin-1A is the principal anterograde motor for neurofilaments, that there may be functional redundancy among isoforms in neurofilament transport, and that anterograde and retrograde neurofilament motors are tightly coordinated.

  10. assessement of the kinetics of the dystrobrevin-Kif5A interaction suggesting that the tertiary structure of dystrobrevin may play a role in regulating its interaction with Kif5a

Kinesin Family Member 5A (KIF5A) 抗原简介

蛋白简介

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.

Gene names and symbols associated with KIF5A

  • kinesin family member 5A (KIF5A) 抗体
  • kinesin family member 5A, a (kif5aa) 抗体
  • kinesin family member 5A (kif5a) 抗体
  • kinesin family member 5A (Kif5a) 抗体
  • D10Bwg0738e 抗体
  • D12S1889 抗体
  • Khc 抗体
  • Kif5 抗体
  • kif5a 抗体
  • Kns 抗体
  • MGC122802 抗体
  • mKIAA4086 抗体
  • MY050 抗体
  • NKHC 抗体
  • si:ch211-166e11.4 抗体
  • SPG10 抗体
  • wu:fj61a10 抗体

Protein level used designations for KIF5A

kinesin family member 5A , kinesin heavy chain isoform 5A-like , KIF5A variant protein , kinesin heavy chain isoform 5A , kinesin heavy chain neuron-specific 1 , kinesin, heavy chain, neuron-specific , neuronal kinesin heavy chain , NKHC , Kinesin heavy chain

GENE ID SPECIES
452019 Pan troglodytes
566086 Danio rerio
100050542 Equus caballus
100124766 Xenopus (Silurana) tropicalis
100339597 Oryctolagus cuniculus
100479975 Ailuropoda melanoleuca
100567274 Anolis carolinensis
3798 Homo sapiens
511273 Bos taurus
16572 Mus musculus
474416 Canis lupus familiaris
314906 Rattus norvegicus
100172845 Pongo abelii
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