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KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008].. 再加上，我们可以发KIF14 抗体 (39) 和 KIF14 蛋白 (3)和数多这个蛋白质的别的产品。
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KIF14 is upregulated in PCa cell lines and clinical PCa tissues. Inhibition of KIF14 suppresses cell proliferation, induces G2 arrest and apoptosis.
In particular, counteracting forces between minus-end-directed kinesin-14 and plus-end-directed kinesin-5 motors have recently been implicated in the regulation of microtubule nucleation.
The mechanochemical cycle of kinesin-14 has been reported.
Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets.
This study identified the mutations in KIF14 as a new cause of primary microcephaly and using cellular experiments demonstrate that impaired cytokinesis, increased apoptosis, and reduced cell motility are features of the associated pathogenesis.
Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 (显示 NEK9 ELISA试剂盒) is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 (显示 KIF20A ELISA试剂盒) and Kif14 to properly coordinate cytokinesis.
Studied overexpression of KIF14 which showed the tight correlation between KIF14 upregulation and inferior clinical outcome in medulloblastoma (MB), suggesting KIF14 is a potential negative prognostic marker in MB. Transient, siRNAs-mediated downregulation of KIF14 suppressed cell proliferation and induced apoptosis in two MB cell lines.
study suggests that KIF14 may serve as a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
analysis of epigenetic regulation of KIF14 overexpression in ovarian cancer
Kinesin-14 blocks microtubule nucleation in yeast and reveal that this inhibition is countered by the kinesin-5 protein, Cut7.[Cut7, Pkl1]
Data provide the first evidence that Kif14 can promote tumor formation in susceptible cells in vivo
The ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket.
Kif14 mutation causes severe brain malformation and hypomyelination.
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997
kinesin family member 14
, kinesin-like protein KIF14
, kinesin-like protein KIF14-like
, N-3 kinesin