Killer Cell Immunoglobulin Like Receptor 2DS1 蛋白 (KIR2DS1)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. 再加上,我们可以发Killer Cell Immunoglobulin Like Receptor 2DS1 抗体 (38)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KIR2DS1 3806 Q14954
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
小麦胚 非结合性   2 μg Log in to see 11至12个工作日
非结合性   20 μg Log in to see 6至8个工作日

KIR2DS1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,

更多Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1)互动伙伴

Human Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) interaction partners

  1. we demonstrated peptide-dependent binding of the activating NK cell receptor KIR2DS1, providing new insights into the underlying mechanisms involved in KIR2DS1-related disorders.

  2. Study findings determined the detrimental impact of KIR2DS1, 2DS5, 3DS1, 2DL5 and CxT4 genotype on genetic predisposition to head and neck squamous cell carcinoma in Iranians.

  3. KIR2DS1 expression by decidual natural killer cells increases their ability to control placental HCMV infection

  4. A negative association between the KIR2DS1 polymorphism and susceptibility to type 1 diabetes mellitus was found.

  5. the surface organization of paired killer Ig-like receptors (KIR), KIR2DL1 and KIR2DS1, on human primary natural killer cells and cell lines, was examined.

  6. KIR2DS1 gene polymorphism is associated with HIV-1 infection.

  7. The absence of KIR-2DS1 in the mother and the presence of HLA-C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA-C2 may contribute to the risk of type 1 diabetes among Han Chinese children

  8. KIR2DS1-C2C2 is less frequent in type 1 diabetes in Saudi children

  9. Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 is Associated with an Increased HLA-C2 Allelic Frequency

  10. functional interactions between KIR and HLA modify risks of BCC and SCC and that KIR encoded by the B genes provides selective pressure for altered p53 in BCC tumors.

  11. The activating KIR gene KIR2DS1 has an important predictive potential for early onset of type 1 autoimmune hepatitis.

  12. Absence of HLA-C2 for donor KIR2DL1 was associated with higher grade II to IV (HR, 1.4; P = .002) and III to IV acute GVHD (HR, 1.5; P = .01) compared with HLA-C2(+) patients.

  13. frequency of the maternal KIR2DS1 gene lower in the preeclampsia group than control group

  14. Data show that KIR2DL5 receptor, KIR2DS1 protein, KIR2DS5 protein and KIR3DS1 receptors were all significantly associated with high viral load.

  15. the frequencies of HLA-Cw07 were statistically significantly higher in the patient group than those in the control group (P = 0.009). KIR2DS1(+) HLA(-) Cw(Lys) was more common in subjects with SLE

  16. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P < 0.05). KIR2DS1 and KIR3DS1

  17. Effect of KIR2DS1 was most significant in pregnancies where its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p = 0.005, odds ratio = 2.65).

  18. Different expression levels of KIR2DL1 may contribute to the abnormal function of natural killer (NK) and NKT lymphocytes, which lead to the risk of systemic lupus erythematosus (SLE) susceptibility.

  19. A negative association was found between the activating KIR2DS1 gene and multiple sclerosis.

  20. Activation of KIR2DS1 positive decidual natural killer cells by HLA-C2 stimulated production of soluble products including GM-CSF.

蛋白简介Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1)


Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS1

  • killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 (KIR2DS1)
  • CD158a 蛋白
  • CD158H 蛋白
  • p50.1 蛋白

Protein level used designations for KIR2DS1

CD158 antigen-like family member H , KIR2DL1-KIR2DS1 , MHC class I NK cell receptor Eb6 ActI , killer cell immunoglobulin-like receptor 2DS1 , killer cell immunoglobulin-like receptor KIRDS1 , killer-cell immunoglobulin-like receptor

3806 Homo sapiens
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