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The protein encoded by KRT3 is a member of the keratin gene family.
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Rabbit Monoclonal KRT3 Primary Antibody for FACS, IHC (p) - ABIN108617
Schermer, Galvin, Sun: Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. in The Journal of cell biology 1986
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Loss of normal CKB (显示 CHKB 抗体) structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT (显示 PCMT1 抗体)-Knockout mouse.
CKB (显示 CHKB 抗体) plays a key role in myotube formation by limiting myoblast fusion during myogenesis.
BCK (显示 CKB 抗体) phosphorylation at Ser6 did not affect its enzymatic activity, but led to the appearance of the phosphorylated enzyme at the endoplasmic reticulum (ER)
Hypothalamic plasticity of neuropeptide Y (显示 NPY 抗体) is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
negative regulation of CKB (显示 CHKB 抗体) by mHTT is a key event in the pathogenesis of HD and contributes to the neuronal dysfunction associated with HD.
reduced expression of brain creatine kinase (显示 CKB 抗体) in the cochlea of Huntington disease (显示 HTT 抗体) mice is associated with hearing impairment
In rat cerebrum and cerebellum, as in rat heart, at all ages the several cCK (显示 CCK 抗体) isoenzymes do participate in a gender-specific manner, in favor of females, in diverse functions of the different cell compartments of glial and neuronal cells.
cytoskeletal dynamics during cell motility is coupled to on-site availability of ATP generated by CKB (显示 CHKB 抗体)
we show that the two PAX6 (显示 PAX6 抗体) isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12 (显示 KRT12 抗体)). PAX6 (显示 PAX6 抗体) isoform-a induced KRT3 expression by targeting its upstream region. KLF4 (显示 KLF4 抗体) enhanced this induction. A combination of PAX6 (显示 PAX6 抗体) isoform-b, KLF4 (显示 KLF4 抗体), and OCT4 (显示 POU5F1 抗体) induced KRT12 (显示 KRT12 抗体) expression
Exon sequencing of KRT3 and KRT12 (显示 KRT12 抗体) in six affected and eight unaffected individuals did not detect any mutations or nucleotide sequence variants in Meesmann epithelial corneal dystrophy.
A novel missense mutation (R503P) in KRT3 leads to MCD in 2 unrelated Taiwanese families.
Location of the E498V mutation emphasizes the functional relevance of the highly conserved boundary motifs at the COOH-terminus of the alpha-helical rod domain in keratin 3 (K3).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
, cytokeratin Ib (human cytokeratin 3)
, creatine kinase B chain
, creatine kinase B-type
, 65 kDa cytokeratin
, cytokeratin 3
, keratin, type II cytoskeletal 3
, type-II keratin Kb3
, K3 keratin
, Type-II keratin Kb3
, keratin K3