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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.
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The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1 (显示 HIF1A ELISA试剂盒)-mediated Warburg effect and angiogenesis.
for IDH (显示 IDH1 ELISA试剂盒), a normal alpha subunit (显示 POLG ELISA试剂盒) is required for catalytic activity and alpha-Arg88 likely participates in the isocitrate site, whereas the beta and gamma subunits have roles in the nucleotide functions of this allosteric enzyme
active sites of the human NAD-IDH are shared between alpha and gamma subunits and between alpha and beta subunits
Asp181 is essential for nicotinamide-adenine dinucleotide (NAD)-specific IDH (显示 IDH1 ELISA试剂盒) alpha subunit (显示 POLG ELISA试剂盒) catalysis and may also facilitate the binding of substrates.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
isocitrate dehydrogenase 3 (NAD+) alpha
, isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
, mitochondrial isocitrate dehydrogenase (nad) subunit alpha
, H-IDH alpha
, NAD(+)-specific ICDH subunit alpha
, NAD(H)-specific isocitrate dehydrogenase alpha subunit
, NAD+-specific ICDH
, isocitrate dehydrogenase (NAD+) alpha chain
, isocitric dehydrogenase subunit alpha
, isocitrate dehydrogenase subunits 3/4