Interleukin 1 delta 蛋白 (FIL1d)

Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). 再加上,我们可以发Interleukin 1 delta 抗体 (85)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FIL1d 54450 Q9QYY1
FIL1d 26525 Q9UBH0
大鼠 FIL1d FIL1d 311783  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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大肠杆菌(E. Coli) 小鼠 非结合性 IL-36Ra (aa 3-156) (mouse) (rec.)  inhibits IL-36α, IL-36β, IL-36γ-dependent expression of IL-6 in mouse BMDCs.  Method: Bone marrow cells were differentiated into bone marrow-derived dendritic cells (BMDCs) using GM-CSF (20ng/ml) for 10 days. BMDCs were cultured with or without IL-36Ra, IL-36α, IL-36β, IL-36γ, or LPS at indicated concentrations for 72 h. Cell supernatants were then harvested and IL-6 levels determined by ELISA. 10 μg Log in to see 5至8个工作日
$224.25
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大肠杆菌(E. Coli) 非结合性 50 μg Log in to see 20至21个工作日
$382.80
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大肠杆菌(E. Coli) 小鼠 非结合性 50 μg Log in to see 20至21个工作日
$382.80
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大肠杆菌(E. Coli) 非结合性   50 μg Log in to see 4 Days
$522.50
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大肠杆菌(E. Coli) 非结合性   50 μg Log in to see 2至3个工作日
$575.00
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大肠杆菌(E. Coli) 小鼠 非结合性 Validation with Western Blot 25 μg Log in to see 8至11个工作日
$218.90
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大肠杆菌(E. Coli) 小鼠 His tag,T7 tag 100 μg Log in to see 15至18个工作日
$800.00
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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FIL1d 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
,
Human , ,
, ,

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Mouse (Murine) Interleukin 1 delta (FIL1d) interaction partners

  1. Interleukin-36 (显示 IL1F6 蛋白) (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity

  2. Transcripts for IL-1F5 are significantly increased in the involved skin of bi- and monotransgenic mice compared with their C57BL controls.

  3. IL-1F5 has unique loop conformations for receptor binding specificity

  4. IL-1F5 mediates anti-inflammatory effects through its ability to induce interleukin-4 (显示 IL4 蛋白) production, as a consequence of its interaction with orphan receptor (显示 NR1D2 蛋白) single Ig IL-1R-related molecule (SIGIRR)/TIR8 (显示 SIGIRR 蛋白).

Human Interleukin 1 delta (FIL1d) interaction partners

  1. IL36RN may be the major disease-causing gene in generalized pustular psoriasis patients in Han population in Sichuan region of China.

  2. IL36RN mutations were strongly linked with early onset and hyponychial pustules, but not with therapeutic efficacy of acitretin or recurrence frequency. Early onset and hyponychial pustules may be specific to IL36RN mutation, however this alone is an insufficient biomarker for acitretin therapy.

  3. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase (显示 ELANE 蛋白), but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.

  4. A study on the association of IL36RN mutations that affect protein expression and function with phenotype in patients with generalized pustular psoriasis.

  5. The findings indicate that IL36RN mutations do not seem to contribute to the pathogenesis of common, nonpustular forms of psoriasis, but to the rarer pustular manifestations such as GPP, acrodermatitis continua suppurativa of Hallopeau and acute generalized exanthematous pustulosis.

  6. Some cases of geographic tongue are caused by IL36RN mutations, while those lacking mutations are associated with an imbalance in expression between IL-36Ra and IL-36gamma proteins in tongue tissue.

  7. Study data and the previous European study suggest that palmoplantar pustulosis is not associated with mutations of the IL36RN gene.

  8. Case Report: short-term infliximab for treatment of juvenile generalized pustular psoriasis with IL36RN mutation.

  9. The authors present a case of strikingly distinct phenotypes seen in two IL36RN mutation carriers from the same nonconsanguineous pedigree. This mutation it appears may influence the age of onset.

  10. We identified a novel homozygous missense mutation in IL36RN in two siblings, and showed the molecular basis of the condition to be both distinct from psoriasis and distinct between the two families studied.

蛋白简介Interleukin 1 delta (FIL1d)

蛋白简介

Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response.

Gene names and symbols associated with Interleukin 1 delta 蛋白 (FIL1d)

  • interleukin 1 family, member 5 (delta) (Il1f5)
  • interleukin 36 receptor antagonist (IL36RN)
  • interleukin 36 receptor antagonist (Il36rn)
  • AI413231 蛋白
  • FIL1 蛋白
  • FIL1(DELTA) 蛋白
  • FIL1D 蛋白
  • Fil1delta 蛋白
  • Il-1h3 蛋白
  • Il1f5 蛋白
  • IL1HY1 蛋白
  • IL1L1 蛋白
  • IL1RP3 蛋白
  • IL36RA 蛋白
  • IL36RN 蛋白
  • PSORP 蛋白

Protein level used designations for Interleukin 1 delta 蛋白 (FIL1d)

IL-1 delta , IL-1F5 , IL-1HY1 , IL-1L1 , interleukin 1 receptor antagonist homolog 1 , interleukin-1 HY1 , interleukin-1 delta , interleukin-1 family member 5 , interleukin-1 homolog 3 , interleukin-1-like protein 1 , interleukin-36 receptor antagonist protein , IL-1 related protein 3 , IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) , IL-1ra homolog 1 , IL1F5 (Canonical product IL-1F5a) , interleukin 1 family, member 5 (delta) , interleukin-1 receptor antagonist homolog 1

GENE ID SPECIES
54450 Mus musculus
26525 Homo sapiens
311783 Rattus norvegicus
518514 Bos taurus
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