The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Rustowska-Rogowska, Gleń, Jarząbek, Rogowski, Rębała, Zabłotna, Czajkowska, Nowicki, Kowalczyk, Sokołowska-Wojdyło: "Interleukin-33 polymorphisms and serum concentrations in mycosis fungoides." in: International journal of dermatology, Vol. 59, Issue 3, pp. 345-351, (2020) (PubMed).
Gungor, Unal, Guclu, Gezer, Eyileten, Guzel, Altunoren, Erken, Oguz, Kocyigit, Yilmaz: "IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival." in: PLoS ONE, Vol. 12, Issue 6, pp. e0178939, (2017) (PubMed).
Bielecka-Dabrowa, Michalska-Kasiczak, Gluba, Ahmed, Gerdts, von Haehling, Rysz, Banach: "Biomarkers and echocardiographic predictors of myocardial dysfunction in patients with hypertension." in: Scientific reports, Vol. 5, pp. 8916, (2015) (PubMed).
Bielecka-Dabrowa, Gluba-Brzózka, Michalska-Kasiczak, Misztal, Rysz, Banach: "The multi-biomarker approach for heart failure in patients with hypertension." in: International journal of molecular sciences, Vol. 16, Issue 5, pp. 10715-33, (2015) (PubMed).