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The protein encoded by ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. 再加上，我们可以发ICOS 抗体 (123) 和 ICOS 蛋白 (14)和数多这个蛋白质的别的产品。
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Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17 (显示 IL17A ELISA试剂盒)-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene.
Our results indicate that ICOS regulates the ontogeny and homeostasis of B6.Sle1 lupus prone mouse T follicular helper (TFH) cells and influences the function of TFH cells during aberrant germinal center B cell responses
The expression of ICOSL (显示 ICOSLG ELISA试剂盒) in the cornea and the ICOS-mediated induction of Foxp3 (显示 FOXP3 ELISA试剂盒)+ CD4 (显示 CD4 ELISA试剂盒)+ regulatory T cells may contribute to successful corneal allograft survival.
this study reveals a previously unknown ICOS-TBK1 (显示 TBK1 ELISA试剂盒) signaling pathway that specifies the commitment of germinal center follicular helper T cells
IFNAR1 (显示 IFNAR1 ELISA试剂盒)-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria
Fecal levels of Crp1 (显示 CRIP1 ELISA试剂盒) were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity.
IL-10 (显示 IL10 ELISA试剂盒) production by CD4 (显示 CD4 ELISA试剂盒)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (显示 IL27 ELISA试剂盒) receptor signaling that is supported after CD4 (显示 CD4 ELISA试剂盒)(+) T cell priming by ICOS signaling.
these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection
the ICOS signaling has a regulatory effect on CD154 (显示 CD40LG ELISA试剂盒)/CD40 (显示 CD40 ELISA试剂盒) expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis.
data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool.
OX40 (显示 TNFRSF4 ELISA试剂盒) and ICOS (显示 CTLA4 ELISA试剂盒) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection
High ICOS (显示 CTLA4 ELISA试剂盒) expression is associated with colorectal neoplasms.
This is the first replication association study of rs4325730 upstream of ICOS (显示 CTLA4 ELISA试剂盒) with AIH in the Japanese population and rs4325730G is a risk allele.
the induction pathway of ICOS (显示 CTLA4 ELISA试剂盒)(+) Foxp3 (显示 FOXP3 ELISA试剂盒)(+) cells was analyzed
ratio of ICOS (显示 CTLA4 ELISA试剂盒)(+) /PD-1 (显示 PDCD1 ELISA试剂盒)(+) Tfh cells and the frequency of IL-21 (显示 IL17C ELISA试剂盒)(+) Tfh cells may be indicators for evaluating the idiopathic membranous nephropathy development
The ICOS (显示 CTLA4 ELISA试剂盒) and ICOSL (显示 ICOSLG ELISA试剂盒) SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases.
Follicular helper T cells differentiation is a multistage process involving BCL6 (显示 BCL6 ELISA试剂盒) and other transcription factors, cytokines, and costimulation through ICOS (显示 CTLA4 ELISA试剂盒) and several other molecules. (Review)
findings show Tregs from inflamed lung of sarcoidosis patients characterized by ICOS (显示 CTLA4 ELISA试剂盒)(high) phenotype; high-level ICOS (显示 CTLA4 ELISA试剂盒) expression was restricted to Tregs from inflamed lung and was absent in blood Tregs of sarcoidosis patients and in lung and blood Tregs of healthy volunteers; potential implication of ICOS/ICOS (显示 CTLA4 ELISA试剂盒)-L (显示 ICOSLG ELISA试剂盒) immune-regulatory axis in in disease activity and resolution
findings indicated that circulating memory Tfh cells, especially CCR7 (显示 CCR7 ELISA试剂盒)+ICOS (显示 CTLA4 ELISA试剂盒)+ memory Tfh cells, may be associated with the relapse of MS and may serve as a new therapeutic target
Expression of mutant caspase-9 (显示 CASP9 ELISA试剂盒) correlated with a downregulation of BAFFR (显示 TNFRSF13C ELISA试剂盒) (B-cell-activating factor (显示 TNFSF13B ELISA试剂盒) belonging to the TNF (显示 TNF ELISA试剂盒) family (BAFF) receptor (显示 TNFRSF13C ELISA试剂盒)) in B cells and ICOS (inducible T-cell costimulator) in T cells.
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
inducible T-cell costimulator
, inducible T-cell co-stimulator
, CD28 and CTLA-4-like protein
, CD28-related protein 1
, activation-inducible lymphocyte immunomediatory molecule
, inducible costimulator