Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) ELISA试剂盒

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia).

list all ELISA KIts 基因 基因ID UniProt
 HIF3A HIF3A 64344 Q9Y2N7
小鼠 HIF3A HIF3A 53417 Q0VBL6
大鼠 HIF3A HIF3A 64345 Q9JHS2
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适于 HIF3A 相互作用对的更多 ELISA 试剂盒

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. AA can protect cardiomyocytes against hypoxia-induced apoptosis through regulating the miR (显示 MLXIP ELISA试剂盒)-1290/HIF3A/HIF-1alpha (显示 HIF1A ELISA试剂盒) axis, and miR (显示 MLXIP ELISA试剂盒)-1290 may be a potential target in the prevention of myocardial ischemia-reperfusion injury

  2. NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (显示 HIF1A ELISA试剂盒)/HIF2alpha (显示 EPAS1 ELISA试剂盒), VEGF (显示 VEGFA ELISA试剂盒)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (显示 BAX ELISA试剂盒) and Bcl2 (显示 BCL2 ELISA试剂盒).

  3. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (显示 ALT ELISA试剂盒) among obese children.

  4. TIMP2 (显示 TIMP2 ELISA试剂盒) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (显示 HIF1A ELISA试剂盒), microRNA-210 (miR (显示 MLXIP ELISA试剂盒)-210), and HIF-3alpha.

  5. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  6. DNA methylation in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN is poorly correlated across tissues, but the DNA methylation in adipose tissue but not blood is highly associated with BMI

  7. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (显示 HIF1A ELISA试剂盒) or Bcl-xL (显示 BCL2L1 ELISA试剂盒), binding proteins of IPAS in the nucleus and mitochondria, respectively.

  8. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (显示 INS ELISA试剂盒) sensitivity.

  9. Parkin (显示 PARK2 ELISA试剂盒) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  10. This provides a compelling model for how hypoxia-induced miR (显示 MLXIP ELISA试剂盒)-429 regulates the switch between HIF-1 (显示 HIF1A ELISA试剂盒) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (显示 HIF1A ELISA试剂盒) levels while simultaneously slowing the progression of HIF3A expression until the miR (显示 MLXIP ELISA试剂盒)-429 levels drop below normoxic levels.

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 (显示 MAPKAPK2 ELISA试剂盒) or MAPKAPK2 (显示 MAPKAPK2 ELISA试剂盒)) enhances the proapoptotic function of IPAS.

  2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (显示 HIF1A ELISA试剂盒)

  3. mRNA of HIF-2alpha (显示 EPAS1 ELISA试剂盒) and Ets-1 (显示 ETS1 ELISA试剂盒) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (显示 CDH5 ELISA试剂盒) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (显示 CDH5 ELISA试剂盒) gene.

  4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf (显示 VEGFA ELISA试剂盒) in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (显示 HIF1A ELISA试剂盒) and HIF-3alpha expression.

  6. alternative splicing and expression of IPAS is induced by hypoxia.

  7. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  8. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (显示 ARNT ELISA试剂盒).

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

HIF3A 抗原简介

Antigen Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HIF3A

  • hypoxia inducible factor 3 alpha subunit (HIF3A) 抗体
  • hypoxia inducible factor 3, alpha subunit (Hif3a) 抗体
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al) 抗体
  • bHLHe17 抗体
  • HIF-3A 抗体
  • HIF3A 抗体
  • Ipas 抗体
  • Mop7 抗体
  • NEPAS 抗体
  • PASD7 抗体
  • zgc:63965 抗体

Protein level used designations for HIF3A

HIF3-alpha-1 , PAS domain-containing protein 7 , basic-helix-loop-helix-PAS protein MOP7 , class E basic helix-loop-helix protein 17 , hypoxia-inducible factor 3-alpha , inhibitory PAS domain protein , member of PAS protein 7 , HIF-3-alpha , HIF3-alpha , hypoxia inducible factor three alpha , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia inducible factor 3, alpha subunit , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like

GENE ID SPECIES
64344 Homo sapiens
53417 Mus musculus
64345 Rattus norvegicus
393376 Danio rerio
456149 Pan troglodytes
476429 Canis lupus familiaris
507699 Bos taurus
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
100621574 Sus scrofa
100071095 Equus caballus
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