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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. 再加上，我们可以发Homeobox A6 蛋白 (6)和数多这个蛋白质的别的产品。
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Human Monoclonal HOXA6 Primary Antibody for ELISA, WB - ABIN516618
Gessner, Thomas, Castro, Büchler, Scholz, Brümmendorf, Soria, Vormoor, Greil, Heidenreich: Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT. in Leukemia 2010
Results demonstrated thatHOXA6 is up-regulated in colorectal cancer (CRC (显示 CALR 抗体)) and promoted cell proliferation, migration and invasion, but inhibited apoptosis, whereas the downregulated expression of HOXA6 produced the opposite effects. HOXA6 regulated apoptosis through the Bcl-2 (显示 BCL2 抗体) signaling pathway, and regulated migration and invasion through the EMT (显示 ITK 抗体) process.
HOXA6 is a signature gene involved in cell growth and sensitivity to chemotherapy in acute myeloid leukemia (显示 BCL11A 抗体) cells.
Data indicate that genes with hypermethylated CpG islands in malignant meningiomas, such as HOXA6 and HOXA9 (显示 HOXA9 抗体), tend to coincide with the binding sites of polycomb (显示 CBX2 抗体) repressive complexes (PRC (显示 PPRC1 抗体)) in early developmental stage.
Enforced overexpression of HOXA6 or HOXA9 (显示 HOXA9 抗体) in FDCP-Mix resulted in increased proliferation and colony formation but had negligible effect on differentiation in early multipotential and later committed precursor cells
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
, homeobox protein Hox-A6
, homeo box 1B
, homeo box A6
, homeobox protein HOXA6
, homeobox protein Hox-1B
, homeobox protein Hox-1.2
, homeobox protein M5-4