Hepatic and Glial Cell Adhesion Molecule (HEPACAM) ELISA试剂盒

The protein encoded by HEPACAM is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. 再加上,我们可以发Hepatic and Glial Cell Adhesion Molecule 抗体 (56)Hepatic and Glial Cell Adhesion Molecule 蛋白 (11)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
HEPACAM 220296 Q14CZ8
HEPACAM 72927 Q640R3
HEPACAM 521015 A4FUY1
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Human Hepatic and Glial Cell Adhesion Molecule (HEPACAM) interaction partners

  1. On the whole, this study indicates that HepaCAM potentially represents a therapeutic target and PF3084014 may prove to a promising agent for use in the treatment of refractory prostate cancer.

  2. hepaCAM associates with connexin 43 (显示 GJA1 ELISA试剂盒), a main component of gap junctions, and enhances connexin 43 (显示 GJA1 ELISA试剂盒) localization to the plasma membrane at cellular junctions.

  3. this study revealed that hepaCAM was downregulated in CRC (显示 CALR ELISA试剂盒) tissues and cell lines. Overexpression of hepaCAM inhibited CRC (显示 CALR ELISA试剂盒) cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC (显示 CALR ELISA试剂盒) tumor growth and metastasis in vivo.

  4. In a group of Egyptian patients with megalencephalic leukoencephalopathy, novel mutations were identified in HEPACAM.

  5. DNMT1 (显示 DNMT1 ELISA试剂盒) up-regulation induced by IL-6 (显示 IL6 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) signaling was indispensable for IL-6 (显示 IL6 ELISA试剂盒)-mediated hepaCAM loss in renal cell carcinoma (RCC (显示 XRCC1 ELISA试剂盒)) cell lines ACHN and 769-P, while DNMT3b (显示 DNMT3B ELISA试剂盒) up-regulation was crucial for hepaCAM loss in A498.

  6. Out of 20 patients, macrocephaly, classic MRI features, motor development delay and cognitive impairment were detected in 20(100%), 20(100%), 17(85%) and 4(20%) patients, respectively. 20(100%) were clinically diagnosed with MLC. 19(95%) were genetically diagnosed with 10 novel mutations in MLC1, MLC1 and GlialCAM mutations were identified in 15 and 4 patients, respectively

  7. HepaCAM depletion was discovered in bladder cancer tissues compared with adjacent normal tissues, and the decreased level was associated with the degradation of FoxO3.

  8. HepaCAM proteins were significantly decreased in bladder carcinoma. Low hepaCAM was not statistically associated with clinicopathological characteristics of the patients. HepaCAM overexpression activated caspase 3 (显示 CASP3 ELISA试剂盒)/8/9, downregulated poly-ADP ribose polymerase (显示 PARP1 ELISA试剂盒) and p-SMAD2 (显示 SMAD2 ELISA试剂盒)/3, and decreased apoptosis.

  9. The suppressive roles of HEPACAM in NSCLC.

  10. Due to the ability to reactivate expression of hepaCAM and inhibit growth of bladder cancer cells, AZAC may represent an effective treatment for bladder cancer.

Mouse (Murine) Hepatic and Glial Cell Adhesion Molecule (HEPACAM) interaction partners

  1. we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.

  2. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule GlialCAM and chloride channel ClC-2, and for changing ClC-2 currents.

  3. GlialCAM, an immunoglobulin-like cell adhesion molecule (显示 MCAM ELISA试剂盒) is expressed in glial cells of the central nervous system.

Hepatic and Glial Cell Adhesion Molecule (HEPACAM) 抗原简介

Antigen Summary

The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.

Gene names and symbols associated with HEPACAM

  • hepatic and glial cell adhesion molecule (HEPACAM) 抗体
  • hepatocyte cell adhesion molecule (Hepacam) 抗体
  • 2900042E01Rik 抗体
  • GlialCAM 抗体
  • Hepn1 抗体
  • MLC2A 抗体
  • MLC2B 抗体

Protein level used designations for HEPACAM

hepatocyte cell adhesion molecule , protein hepaCAM

GENE ID SPECIES
100064233 Equus caballus
220296 Homo sapiens
489305 Canis lupus familiaris
521015 Bos taurus
72927 Mus musculus
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