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may be involved in osteoblast recruitment into growing bone tissue. 再加上，我们可以发Hemogen 抗体 (62) 和 和数多这个蛋白质的别的产品。
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HOXB4 binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units.
Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment
Using ex vivo culture and HSC transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
EDAG-1 regulates the proliferation and apoptosis of thyroid carcinoma via the PI3K/Akt signaling pathway.
EDAG forms complex with GATA1 and p300 and increases GATA1 acetylation and transcriptional activity by facilitating the interaction between GATA1 and p300
EDAG enhances the protein stability of NPM1 via binding to NPM1, which plays a critical role in the anti-apoptosis of leukaemia cells.
EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA-1 and its target genes
results suggest a novel function of nuclear negative differentiation regulator (NDR) protein in regulating hematopoietic cell development [NDR]
These results suggest that EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of NF-kappa B.
Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 in leukemia cells
The stable transfected cells were identified with RT-PCR and the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed.
The inhibition of the EDAG gene by PMA is mediated through down-regulation of transcription factor GATA-1 .
may be involved in osteoblast recruitment into growing bone tissue
, hemopoietic gene protein
, negative differentiation regulator protein
, nuclear protein
, erythroid differentiation gene 1
, erythroid differentiation-associated gene protein