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may be involved in osteoblast recruitment into growing bone tissue.
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HOXB4 (显示 HOXB4 ELISA试剂盒) binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units.
Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment
Using ex vivo culture and HSC transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34 (显示 CD34 ELISA试剂盒)+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34 (显示 CD34 ELISA试剂盒)+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (显示 MPO ELISA试剂盒), CEACAM8, CRISP3 (显示 CRISP3 ELISA试剂盒), MS4A3, CEACAM6, HEMGN, and MMP8 (显示 MMP8 ELISA试剂盒)
EDAG-1 regulates the proliferation and apoptosis of thyroid carcinoma via the PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) signaling pathway.
EDAG forms complex with GATA1 (显示 GATA1 ELISA试剂盒) and p300 (显示 EP300 ELISA试剂盒) and increases GATA1 (显示 GATA1 ELISA试剂盒) acetylation and transcriptional activity by facilitating the interaction between GATA1 (显示 GATA1 ELISA试剂盒) and p300 (显示 EP300 ELISA试剂盒)
EDAG enhances the protein stability of NPM1 (显示 NPM1 ELISA试剂盒) via binding to NPM1 (显示 NPM1 ELISA试剂盒), which plays a critical role in the anti-apoptosis of leukaemia cells.
EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA-1 (显示 GATA1 ELISA试剂盒) and its target genes
results suggest a novel function of nuclear negative differentiation regulator (NDR) protein in regulating hematopoietic cell development [NDR]
These results suggest that EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of NF-kappa B (显示 NFKB1 ELISA试剂盒).
Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 (显示 GATA1 ELISA试剂盒) in leukemia cells
The stable transfected cells were identified with RT-PCR and the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed.
may be involved in osteoblast recruitment into growing bone tissue
, hemopoietic gene protein
, negative differentiation regulator protein
, nuclear protein
, erythroid differentiation gene 1
, erythroid differentiation-associated gene protein