Heat Shock Protein 70 蛋白 (HSP70)

heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons [RGD, Feb 2006].. 再加上,我们可以发HSP70 抗体 (780)HSP70 试剂盒 (80)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HSP70 3308 P34932
小鼠 HSP70 HSP70 15511 P17879
大鼠 HSP70 HSP70 266759 O88600
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antibodies-online.cn销售最多的HSP70 蛋白

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag   100 μg Log in to see 2至3个工作日
Baculovirus His tag   100 μg Log in to see 2至3个工作日
Baculovirus 非结合性   100 μg Log in to see 2至3个工作日
大肠杆菌(E. Coli) His tag 50 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) 非结合性   50 μg Log in to see 5至8个工作日
大肠杆菌(E. Coli) 非结合性   100 μg Log in to see 2至3个工作日
大肠杆菌(E. Coli) His tag   100 μg Log in to see 15至17个工作日
大肠杆菌(E. Coli) Chlamydia trachomatis 非结合性   100 μg Log in to see 2至3个工作日
大肠杆菌(E. Coli) Bacteria 非结合性   100 μg Log in to see 11至16个工作日
大肠杆菌(E. Coli) GST tag   50 μg Log in to see 10至12个工作日

HSP70 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,

引用最多的HSP70 蛋白

  1. Human HSP70 Protein expressed in Escherichia coli (E. coli) - ABIN1686670 : Zou, Guo, Guettouche, Smith, Voellmy: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. in Cell 1998 (PubMed)
    Show all 12 Pubmed References

  2. Human HSP70 Protein expressed in Baculovirus - ABIN1686688 : Rothman: Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells. in Cell 1990 (PubMed)
    Show all 8 Pubmed References

  3. Human HSP70 Protein expressed in Escherichia coli (E. coli) - ABIN593443 : Mosenson, Zloza, Nieland, Garrett-Mayer, Eby, Huelsmann, Kumar, Denman, Lacek, Kohlhapp, Alamiri, Hughes, Bines, Kaufman, Overbeck, Mehrotra, Hernandez, Nishimura, Guevara-Patino, Le Poole: Mutant HSP70 reverses autoimmune depigmentation in vitiligo. in Science translational medicine 2013 (PubMed)

更多Heat Shock Protein 70 (HSP70)互动伙伴

Human Heat Shock Protein 70 (HSP70) interaction partners

  1. The level of Hsp70 was higher in the allergic rhinitis (AR) group compared with the non-AR group. Furthermore, treatment of HNE (显示 ELANE 蛋白) cells with Th2 cytokines induced secretion of Hsp70 into the extracellular area, and did not influence the production of Hsp70. These results suggest that Hsp70 may play a major role in the pathogenesis of AR.

  2. The article results indicate that the heat-shock protein HSP70-2 (显示 HSPA1B 蛋白) (+1538 A/G) and HSP70-hom (显示 HSPA1L 蛋白) (+2437 C/T) SNPs are highly associated with renal complications in Type 2 Diabetes Mellitus among the South Indian population.

  3. HSP70-Hrd1 (显示 SYVN1 蛋白) axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 (显示 PRDM1 蛋白) mutants.

  4. verified the interaction of cellular chaperon HSP70 with Porcine reproductive and respiratory syndrome virus NSP12, and demonstrated that NSP12 could recruit HSP70 to maintain its own stability and benefit for the virus replication

  5. Modulatory action of extracellular HSP70 on A549 inflammatory response through RAGE (显示 AGER 蛋白) was able to evoke important expression changes in monocyte, showing its relevance in influencing the interaction between cancer and immune system cell.

  6. Here the authors show that in budding yeast, Hsf1 (显示 HSF1 蛋白) basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 (显示 HSF1 蛋白) activity.

  7. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin (显示 PARK2 蛋白) Function. Heat shock protein members may act as compensatory factors for parkin (显示 PARK2 蛋白) loss of function and that the exploitation of these factors may be of potential therapeutic value.

  8. targeting the Hsp70 induction in Hsp90 (显示 HSP90 蛋白) inhibitor-treated cancer cells and tumor vasculature cells may beneficially enhance the radiosensitizing effect

  9. The interaction of Fas receptor (显示 FAS 蛋白) with FasL (显示 FASL 蛋白) leads to an activation of the Tag7 (显示 PGLYRP1 蛋白)-Hsp70 complex in the lymphocyte membrane fraction, and here FasL (显示 FASL 蛋白) acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (显示 MICA 蛋白) stress ligand with the NKG2D (显示 KLRK1 蛋白) receptor is necessary for the release of this cytotoxic complex

  10. Triptolide downregulates Sp1 (显示 PSG1 蛋白) and HSP70 mRNA in gastric cancer cell lines.

Tomato (Solanum lycopersicum) Heat Shock Protein 70 (HSP70) interaction partners

  1. Experimental evidence show: apoptozole forms aggregates under aqueous conditions that could interact with HSP70 proteins in a non-specific manner.

  2. Disrupts the Hsp70-Bag3 (显示 BAG3 蛋白) interaction.

  3. Increased Hsp70 expression levels are associated with squamous cell carcinoma of the head and neck.

  4. Hsp70 and Hsp90 (显示 HSP90 蛋白) chaperones coregulate heat shock gene expression within a network of mutual, but factor-specific, interactions with heat stress transcription factors.

  5. salicylic acid-mediated potentiation of Hsp70 is due to modulation of heat shock factors by salicylic acid.

Pig (Porcine) Heat Shock Protein 70 (HSP70) interaction partners

  1. HSP70 indirectly interacted with Smad3 (显示 SMAD3 蛋白).

  2. There was a significant decrease in the systemic HSP70 levels of trauma groups (moderate and severe hemorrhage) when compared to the sham trauma group, which was significantly decreased compared to baseline values in severe hemorrhage over the entire time course.

  3. Host HSP70 and Classical swine fever virus NS5A protein complex formation is confirmed by coimmunoprecipitation and GST-pulldown studies.

  4. This study evaluated the expression of 70kDa (显示 RPS6KB1 蛋白) heat shock proteins and the concentration of thiobarbituric acid reactive substances and nitric oxide ions as markers of oxidative stress in swine.

  5. This study revealed that HSP70 is an essential host factor required for the replication of porcine reproductive and respiratory syndrome virus.

  6. A specific interaction between Hsp70 and porcine circovirus type 2 Cap (capsid protein) was confirmed by colocalization by confocal microscopy and co-immunoprecipitation.

  7. This work investigated the expression of heat shock protein 70 by Western blot in swine liver. Animals in an intensive/indoor confinement system showed significantly higher HSP70 values compared with those in an extensive/outdoor system.

  8. The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.

  9. These results indicated that the expression of Hsp70 in the intestinal piglets was upregulated by IUGR, and different intestinal sites had different responses to stress.

  10. Induction of tolerance to heat shock correlated with the induced expression of heat shock protein 70. HSP70 and compatible osmolytes have distinct roles in cellular adaptation to these stresses.

Arabidopsis thaliana Heat Shock Protein 70 (HSP70) interaction partners

  1. ability of multiple unrelated Hsp70-binding elements to support protein import verified that the majority of TPs utilize an N-terminal Hsp70-binding domain during translocation and expand the mechanistic view of the import process

  2. temperature regulated expression of AtHSP70-4 may be mediated by cell cycle transcription factors and participate in plant acclimations to non-stress temperature changes

  3. This work describes a detailed quantitative interaction study between the novel plastidial chaperone receptor OEP61 and isoforms of the chaperone types Hsp70 and Hsp90 (显示 HSP90 蛋白) using the optical method of total internal reflection ellipsometry.

  4. Hsp70-14 and Hsp70-15 silenced plants display an altered stomatal response and a constitutive heat stress phenotype.

  5. Chloroplasts have two chaperone systems facilitating protein translocation into the stroma: the cpHsc70 system and the Hsp93/Tic40 system.

  6. A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert.

  7. Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (显示 Psmd4 蛋白) system.

  8. The MAPK (显示 MAPK1 蛋白)-EGR-1 (显示 EGR1 蛋白)-HSP70 pathway regulates the cigarette smoke-induced inflammatory process.

Mouse (Murine) Heat Shock Protein 70 (HSP70) interaction partners

  1. Extracellular Hsp70 and Hsp90 (显示 HSP90 蛋白), either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia.

  2. HSP70 functions as a negative regulator in the TGF-beta (显示 TGFB1 蛋白)- stimulated VEGF (显示 VEGFA 蛋白) synthesis in osteoblasts, and that the suppressive effect of HSP70 is exerted via regulation of p38 MAP kinase (显示 MAPK14 蛋白).

  3. The data implicate an involvement of Hsp70 oxidatively damaged protein degradation by the 20S proteasome (显示 PSMA5 蛋白).

  4. interaction between BAG3 (显示 BAG3 蛋白) and HSP70 is essential for BAG3 (显示 BAG3 蛋白) to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis

  5. Data show that Klotho (显示 KL 蛋白) protein is present in the heart, and reduced levels of myocardial Klotho (显示 KL 蛋白) in aging mice is accompanied by lower levels heat shock protein 70 (HSP70) in the myocardium.

  6. analysis of the intracellular pathways implicated in Hsp70 regulated signal transduction showed the involvement of both PI3K/AKT (显示 AKT1 蛋白) and NF-kappaB (显示 NFKB1 蛋白).

  7. HSPA1A (显示 HSPA1A 蛋白)/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice

  8. Hsp70 expression was observed trophoblast cells and decidual cells and was relatively constant throughout the pregnancy.

  9. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7 (显示 PGLYRP1 蛋白)-Hsp70 and the Tag 7 (显示 PGLYRP1 蛋白) component of this complex with TNFR1 (显示 TNFRSF1A 蛋白) receptor in solution and in tumor cells are presented.

  10. the protective effect of HSP70 may be associated with inhibition of NF-kappaB and stimulation of NOS/NO signaling pathways

Cow (Bovine) Heat Shock Protein 70 (HSP70) interaction partners

  1. A new SNP in the 3'-UTR of the hsp 70-1 gene in Bos taurus and Bos indicus

  2. The purified 44-kD ATPase domain from HSP70 exhibited intrinsic ATP-ADP exchange activity and acid-stable autophosphorylation at Thr204.

  3. The effect of culture conditions on expression of heat shock protein 70 and Bax (显示 BAX 蛋白) protein in bovine blastocysts is reported.

  4. that HSC70 (显示 HSPA8 蛋白) preconditioning (1) attenuates the TNF-alpha (显示 TNF 蛋白) response to endotoxin in macrophages in vitro, (2) induces cardiac functional tolerance to endotoxin and (3) reduces NF-kappaB (显示 NFKB1 蛋白) activity, and TNF-alpha (显示 TNF 蛋白) and ICAM-1 (显示 ICAM1 蛋白) levels in heart tissue.

  5. the presence of SNPs (C/- and G/T) in the 5'-UTR region of inducible Hsp70.1 (显示 HSPA1A 蛋白) ameliorates HS response and tolerance to heat of bovine peripheral blood mononuclear cells

  6. This study showed that Hsp70 concentration is a reliable indicator of chronic stress but is not a reliable indicator of a single stressor when animals are exposed to multiple chronic stressors.

  7. Heat shock increased both HSP70 and IFNT expression in blastocysts.

  8. the promoter region of bovine hsp70.1 (显示 HSPA1A 蛋白) gene is polymorphic and may be useful in selection of dairy cows for relatively better thermotolerance and higher milk production.

  9. More DNMT1 (显示 DNMT1 蛋白) mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (显示 ASCL2 蛋白) mRNA was present at highest levels in transgenic SCNT embryos.

  10. In Sahiwal cattle the mRNA expression of HSP70 and its protein concentration were higher (P<0.05) during peak summer (44 degrees C) and winter (10 degrees C) as compared to Frieswal cattle. This investigation supports the earlier information on the higher adaptability of indigenous cattle breeds to hot and humid conditions compared to the crossbreds of temperate cattle breeds.



heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons

Gene names and symbols associated with Heat Shock Protein 70 蛋白 (HSP70)

  • heat shock protein family A (Hsp70) member 4 (HSPA4)
  • CG5834 gene product from transcript CG5834-RA (Hsp70Bbb)
  • heat shock protein 70 (HSP70)
  • heat shock protein family A (Hsp70) member 6 (HSPA6)
  • heat shock 70kDa protein 2 (HSPA2)
  • heat shock 70 kD protein cognate (HSP70)
  • chloroplast heat shock protein 70-2 (cpHsc70-2)
  • Heat shock protein 70 (Hsp 70) family protein (Hsp70-15)
  • Hsp70 family chaperone (HSP70)
  • Heat shock protein 70 (PCC7424_2419)
  • Heat shock protein 70 (Isop_1041)
  • Heat shock protein 70, putative (CGB_C3390W)
  • Heat shock protein 70 (Bacsa_1698)
  • heat shock protein 70 (dnaK-B)
  • heat shock protein 70 (LOC100305036)
  • heat shock protein 1B (Hspa1b)
  • heat shock protein family A member 4 (Hspa4)
  • heat shock cognate protein 70a (hsc70a)
  • heat shock 70kDa protein 1A (HSPA1A)
  • heat shock protein 1 (hsp1)
  • Heat Shock Protein (hsp-70)
  • heat shock cognate 70-kd protein (hsp70)
  • APG-2 蛋白
  • ATHSP70 蛋白
  • CG5834 蛋白
  • CG31354 蛋白
  • chloroplast heat shock protein 70-2 蛋白
  • cpHsc70-2 蛋白
  • DmelCG5834 蛋白
  • F19K16.12 蛋白
  • F19K16_12 蛋白
  • HS24/P52 蛋白
  • hsc70 蛋白
  • HSC70-7 蛋白
  • hsc71 蛋白
  • hsp68 蛋白
  • Hsp70 蛋白
  • Hsp70-1 蛋白
  • HSP70-2 蛋白
  • hsp70-5 蛋白
  • Hsp70.1 蛋白
  • hsp70B 蛋白
  • HSP70B' 蛋白
  • Hsp70Bb 蛋白
  • hsp70Bb-prime 蛋白
  • hsp70RY 蛋白
  • Hsp110 蛋白
  • HSPA1 蛋白
  • HSPA1B 蛋白
  • HSPA2 蛋白
  • HSPA6 蛋白
  • HSPH2 蛋白
  • irp94 蛋白
  • K9P8.5 蛋白
  • K9P8_5 蛋白
  • LOC100305036 蛋白
  • RY 蛋白

Protein level used designations for Heat Shock Protein 70 蛋白 (HSP70)

heat shock 70 kDa protein 4 , heat shock 70-related protein APG-2 , heat shock 70kD protein 4 , heat shock protein, 110 kDa , hsp70 RY , Hsp70Bbb , CG5834-PA , Hsp70Bbb-PA , heat shock 70 kDa protein 1 , Heat shock 70 kDa protein 6 , heat shock 70 kDa protein , heat shock 70 kDa protein B' , dnaK-type molecular chaperone , heat shock protein 70 , heat shock 70 kD protein cognate , hypothetical protein , Heat shock protein 70 , CF Hsp70 , Heat shock cognate 71 kDa protein , 68 kDa heat shock protein , heat shock 70 kDa protein 1B , heat shock 70kDa protein 1B , heat shock protein 70.1 , heat shock protein, 70 kDa 1 , ischemia responsive 94 kDa protein , HSP70 , heat shock 70kDa protein 8 , heat shock cognate 70 kDa protein , 70 kda heat shock protein-2 , HSP70.2 , chaperone , heat shock 70 kD protein 2 , heat shock 70 kDa protein 2 , heat-shock 70-kilodalton protein 1B , CL45_1 , CL45_1(648) , CL45_1_ov , Heat shock 70 kDa protein , heat shock protein 70 kDa , hsp 70-1 , npi119-hsp1 , heat shock 70 kDa protein 1A/1B , Heat shock cognate 70 kDa protein , heat shock cognate 70-kd protein

3308 Homo sapiens
50022 Drosophila melanogaster
403612 Canis lupus familiaris
100134914 Solanum lycopersicum
396906 Sus scrofa
423504 Gallus gallus
692373 Bombyx mori
820438 Arabidopsis thaliana
835054 Arabidopsis thaliana
844332 Arabidopsis thaliana
3636229 Candida albicans SC5314
7095334 Grapevine leafroll-associated virus 10
7110730 Cyanothece sp. PCC 7424
10155152 Isosphaera pallida ATCC 43644
10187290 Cryptococcus gattii WM276
10259602 Bacteroides salanitronis DSM 18170
10889164 Simkania negevensis Z
100305036 Ictalurus punctatus
15511 Mus musculus
266759 Rattus norvegicus
100135841 Oncorhynchus mykiss
282254 Bos taurus
542423 Zea mays
100913152 Ovis aries
172757 Caenorhabditis elegans
100301691 Oncorhynchus mykiss
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