HLA Class II DO alpha 蛋白 (HLA-DOA)

HLA-DOA belongs to the HLA class II alpha chain paralogues. 再加上,我们可以发HLA-DOA 抗体 (36)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HLA-DOA 3111 P06340
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
大肠杆菌(E. Coli) His tag 100 μg Log in to see 13至16个工作日
小麦胚 GST tag 2 μg Log in to see 11至12个工作日

HLA-DOA 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,

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Human HLA Class II DO alpha (HLA-DOA) interaction partners

  1. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

  2. pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

  3. significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene.

  4. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population

  5. HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies.

  6. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity

  7. results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation

  8. analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis

  9. HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias.

  10. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.

  11. These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy.

  12. four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing

  13. minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product.

  14. HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1.



HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

Gene names and symbols associated with HLA Class II DO alpha 蛋白 (HLA-DOA)

  • major histocompatibility complex, class II, DO alpha (HLA-DOA)
  • HLA-DNA 蛋白
  • HLA-DZA 蛋白
  • HLADZ 蛋白

Protein level used designations for HLA Class II DO alpha 蛋白 (HLA-DOA)

HLA class II histocompatibility antigen, DO alpha chain , HLA-D0-alpha , MHC DN-alpha , MHC DZ alpha , MHC class II antigen DOA , lymphocyte antigen , major histocompatibility complex, class II, DN alpha

3111 Homo sapiens
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