anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) 抗体

may play a role in D5 dopamine receptor signal transduction and renal sodium transport. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GNA12 2768 Q03113
GNA12 81663 Q63210
GNA12 14673 P27600
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Showing 10 out of 70 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB Rabbit Anti-GNA12 Antibody Catalog Number: ARP54813_P050 Formalin Fixed Paraffin Embedded Tissue: Human Ovary Tissue Observed Staining: Plasma membrane Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec WB Suggested Anti-GNA12 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Liver 100 μL 2至3个工作日
$289.00
详细
Cow 非结合性 WB 100 μL 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, WB   100 μg 6至7个工作日
$429.84
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非结合性 EIA, WB 0.4 mL 6至8个工作日
$484.00
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Cow 非结合性 WB 100 μL 11至14个工作日
$551.83
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti GNA12/G protein alpha 12 Polyclonal Antibody, Unconjugated (ABIN753958) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日
$317.90
详细
非结合性 WB Western Blot at 1:1000 dilution Lane 1: A2058 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. 400 μL 2至3个工作日
$515.63
详细
非结合性 ELISA, WB Western blot analysis of GNA12 expression in NT2D1 whole cell lysate,The lane on the left is treated with the antigen-specific peptide. 100 μL 11至12个工作日
$390.77
详细
山羊 非结合性 ELISA, WB ABIN4902641 (0.3µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN4902641 (1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μL 11至13个工作日
$457.22
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大鼠 非结合性 ELISA, WB   1 mL 11至14个工作日
$947.83
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更多抗GNA12的相互作用对抗体

Human Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

  1. Galpha12 plays a crucial role in human airway smooth muscle contraction via RhoA-dependent activation of the PI3K/ROCK axis; targeting Galpha12 signaling may elucidate novel therapeutic targets in asthma

  2. the current studies provide evidence showing that c-Jun directly binds to a consensus binding sequence within the GNA12-5' regulatory region, thereby regulating GNA12 transcription.

  3. we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR-155 expression.

  4. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.

  5. preeclampsia is associated with decreased methylation of the GNA12 promoter

  6. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation.

  7. Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.

  8. Results show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription.

  9. A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.

  10. Galpha12gep oncogene inhibits FOXO1, which may result from the inhibition of FOXO1 de novo synthesis by miR-135b in conjunction with MDM2-mediated destabilization of FOXO1.

  11. CREB is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene stimulated oncogenic signaling in ovarian cancer cells.

  12. Galpha12 drives oral squamous cell carcinoma invasion through the up-regulation of IL-6 and IL-8 cytokines.

  13. Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression,proteinuria and glomerulosclerosis.

  14. study implicates a G12-stimulated mitogen-activated protein kinase cascade in cancer cell invasion, and supports a role for JNK in cancer progression.

  15. In an independent set of 40 banked placental specimens, GNA12 was overexpressed during preeclampsia when co-incident with chronic hypertension

  16. that Galpha(i2)-induced signaling can act as a counterbalance to MuRF1-mediated atrophy, indicating that receptors that act through Galpha(i2) might represent potential targets for preventing skeletal muscle wasting.

  17. Overexpression of Galpha(s) or Galpha(12) active mutants enhanced androgen-induced androgen receptor transactivation. Galpha(s) active mutant sensitized androgen receptor to castration-level of androgen (R1881).

  18. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase

  19. A functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway.

  20. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.

Zebrafish Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

  1. Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA

  2. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

  1. results demonstrate that Galpha12 regulates SIRT1-dependent mitochondrial respiration through HIF-1alpha-dependent USP22 induction, identifying Galpha12 as an upstream molecule that contributes to the regulation of mitochondrial energy expenditure.

  2. The results of this study suggest that a balance in the expression of Go1alpha and Go2alpha sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system.

  3. Galpha12 plays a role in differentiation through NFATc1 and in cell migration and resorption activity through RhoA during osteoclastogenesis.

  4. Galpha12 is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.

  5. Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 to mediate this process.

  6. Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.

  7. Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA

  8. results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.

  9. Pkd1 mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 that increases the shedding of E-cadherin in kidney epithelial cells.

  10. Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin-induced vWF secretion, in a process involving SNAP, Galpha12/13 and Galphaq/11

  11. Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

  12. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.

  13. Expression analysis reveals that production of 5-HT7 and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.

  14. that Galpha(i2)-induced signaling can act as a counterbalance to MuRF1-mediated atrophy, indicating that receptors that act through Galpha(i2) might represent potential targets for preventing skeletal muscle wasting.

  15. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase

  16. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.

  17. These results suggest that Galpha12 may be a critical signaling molecule in TCR-induced IL-2 production and also relay a signal to suppress Th2 and Th17 cell differentiation.

  18. The G alpha(12)-mediated signaling pathway functionally interacts not only with the G alpha(13)- but also with the G alpha(q/11)-mediated signaling systems.

  19. Hsp90 binding and acylation of Galpha12 results in localization to lipid rafts

  20. data clearly show that Galpha12/Galpha13 proteins as well as Galphaq/Galpha11 protein alone can couple G-protein-coupled receptors to the rapid activation of ras homolog gene family member A(RhoA)

GNA12 抗原简介

蛋白简介

may play a role in D5 dopamine receptor signal transduction and renal sodium transport

Gene names and symbols associated with GNA12

  • G protein subunit alpha 12 (GNA12) 抗体
  • G protein subunit alpha 12 (Gna12) 抗体
  • guanine nucleotide binding protein (G protein) alpha 12a (gna12a) 抗体
  • guanine nucleotide binding protein, alpha 12 (Gna12) 抗体
  • AI414047 抗体
  • AI504261 抗体
  • Galpha12 抗体
  • gep 抗体
  • gna12 抗体
  • gna12l 抗体
  • NNX3 抗体
  • RMP 抗体

Protein level used designations for GNA12

G-protein subunit alpha-12 , WUGSC:H_GS165O14.2 , g alpha-12 , guanine nucleotide-binding protein subunit alpha-12 , guanine nucleotide binding protein, alpha 12 , Galpha 12 , guanine nucleotide binding protein (G protein) alpha 12

GENE ID SPECIES
2768 Homo sapiens
81663 Rattus norvegicus
769924 Gallus gallus
515159 Bos taurus
503589 Danio rerio
14673 Mus musculus
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