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The product of GRB14 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.
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Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.
The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor (显示 INSR ELISA试剂盒) signaling.
Data show that Grb14 inhibits the activity of PTP1B (显示 PTPN1 ELISA试剂盒) in retina in a phosphorylation-regulated (显示 PHAX ELISA试剂盒) manner, and that rhodopsin (显示 RHO ELISA试剂盒)-regulated Src kinase (显示 CSK ELISA试剂盒) activation in retina leads to the phosphorylation of Grb14.
Grb14 is a normal physiological modulator of CNG channel function in vivo.
Grb14 functions in vivo as a tissue-specific modulator of insulin (显示 INS ELISA试剂盒) action, most likely via repression of IR-mediated IRS-1 (显示 IRS1 ELISA试剂盒) tyrosine phosphorylation
regulation of Grb14 expression in adipose tissue may play a physiological role in insulin (显示 INS ELISA试剂盒) sensitivity
Grb14 exerts a dual role on the regulation by insulin (显示 INS ELISA试剂盒) of hepatic metabolism. It inhibits insulin receptor (显示 INSR ELISA试剂盒) catalytic activity, and as a sterol regulatory element binding protein (显示 CNBP ELISA试剂盒)-1c maturation.
These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.
Grb10 (显示 GRB10 ELISA试剂盒) and Grb14 have roles in regulation of insulin (显示 INS ELISA试剂盒) signaling and glucose homeostasis
We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 (显示 KCNQ1 ELISA试剂盒) showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin (显示 INS ELISA试剂盒) sensitivity.
The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor (显示 INSR ELISA试剂盒) complex formation through phosphorylation, in addition to other domains.
Data suggest that GRB10 (显示 GRB10 ELISA试剂盒) and GRB14 are both Ca2 (显示 CA2 ELISA试剂盒)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (显示 GRB10 ELISA试剂盒) and GRB14, as compared to a single one present in GRB7 (显示 GRB7 ELISA试剂盒). (GRB10 (显示 GRB10 ELISA试剂盒) = growth factor receptor-bound protein 10 (显示 GRB10 ELISA试剂盒); GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 (显示 GRB7 ELISA试剂盒) = growth factor receptor-bound protein 7 (显示 GRB7 ELISA试剂盒))
Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor (显示 INSR ELISA试剂盒).
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1 (显示 STAB1 ELISA试剂盒), PIGC, ZNRF3, GRB14
Modulation of mouse rod photoreceptor responses by Grb14 protein.
ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin (显示 INS ELISA试剂盒) resistance.
Studies indicate that insulin receptor (IR (显示 INSR ELISA试剂盒)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (显示 GRB10 ELISA试剂盒)/14 and SH2B1 (显示 SH2B1 ELISA试剂盒)/B2 adaptors.
Grb14 is the first negative regulator of CEACAM3 (显示 CEACAM3 ELISA试剂盒)-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact
These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.
The growth factor receptor (显示 RYK ELISA试剂盒) bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor (显示 INSR ELISA试剂盒) substrate (IRS)-1 (显示 IRS1 ELISA试剂盒) functions in the retina.
Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
growth factor receptor-bound protein 14
, growth factor receptor-bound protein 14-like
, GRB14 adapter protein
, growth factor receptor bound protein 14