Golgin, RAB6-Interacting 蛋白 (GORAB)

GORAB encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. 再加上,我们可以发Golgin, RAB6-Interacting 抗体 (83)Golgin, RAB6-Interacting 试剂盒 (7)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GORAB 92344 Q5T7V8
GORAB 98376 Q8BRM2
GORAB 304923 B1H222
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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GORAB 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

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Human Golgin, RAB6-Interacting (GORAB) interaction partners

  1. Novel compound heterozygous nonsense mutations were identified in the GORAB gene of a geroderma osteodysplastica patient.

  2. in the present study a de novo deletion on 1q23.3-q24.2 combined with a GORAB missense mutation leads to a distinctive phenotype with features from Gerodermia osteodysplastica and also short stature, cutis laxa, frequent fractures, facial dysmorphism, cup-shaped ears and intellectual disability

  3. SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F (显示 CCNF 蛋白) and RRM2 (显示 RRM2 蛋白) proteins, thus constituting a dual regulatory circuit

  4. rs17684886 (ZNRF1 (显示 ZNRF1 蛋白)) and rs599019 (COLEC12 (显示 COLEC12 蛋白)) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5 (显示 API5 蛋白)) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes

  5. SCYL1-BP1 plays a critical role in the regulation of EEA1 (显示 EEA1 蛋白), BMPR2 (显示 BMPR2 蛋白) and BRCA2 (显示 BRCA2 蛋白) expression.

  6. SCYL1BP1 can promote the degradation of MDM2 (显示 MDM2 蛋白) protein and further inhibit the G1/S transition of lung SCC (显示 CYP11A1 蛋白) lines. Reintroduction of SCYL1BP1 into lung SCC (显示 CYP11A1 蛋白) lines significantly inhibited cell proliferation, migration, invasion and tumor formation.

  7. Data suggest that SCYL1-BP1 is a novel regulator of the MDM2 (显示 MDM2 蛋白)-p53 (显示 TP53 蛋白) feedback loop and that it may be a potential tumor suppressor.

  8. The chemotaxis signal pathway induced by chemokines CKbeta8 (显示 CCL23 蛋白) and CKbeta8 (显示 CCL23 蛋白)-1 is mediated via the Gi/Go protein, phospholipase C (PLC (显示 PLC 蛋白)) and protein kinase C delta (PKC delta (显示 PKCd 蛋白)).

  9. study supplements the limited available data on SCYL1BP1 and further establishes deficiency of this recently described golgin as the only known cause of geroderma osteodysplastica

  10. assessment of interaction with hPirh2 (显示 RCHY1 蛋白)

Mouse (Murine) Golgin, RAB6-Interacting (GORAB) interaction partners

  1. Gorab role in the abnormal osteoblast differentiation in the gerodermia osteodysplastica

  2. The G59S mutation in p150(glued) protein abrogates the normal function of the protein and accelerates motor neuron degeneration.

蛋白简介Golgin, RAB6-Interacting (GORAB)

蛋白简介

This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with Golgin, RAB6-Interacting 蛋白 (GORAB)

  • golgin, RAB6 interacting (GORAB)
  • golgin, RAB6-interacting (Gorab)
  • AI467484 蛋白
  • GO 蛋白
  • NTKL-BP1 蛋白
  • NTKLBP1 蛋白
  • Scyl1bp1 蛋白

Protein level used designations for Golgin, RAB6-Interacting 蛋白 (GORAB)

N-terminal kinase-like-binding protein 1 , NTKL-binding protein 1 , RAB6-interacting golgin , SCY1-like 1 binding protein 1 , SCY1-like 1-binding protein 1 , SCYL1-BP1 , SCYL1-binding protein 1 , hNTKL-BP1 , dynactin 1, isoform 1; dynactin 1 (p150, Glued homolog); p150, Glued homolog; 150 kDa dynein-associated polypeptide; p150-glued , mNTKL-BP1 , NTKL-BP1

GENE ID SPECIES
92344 Homo sapiens
98376 Mus musculus
304923 Rattus norvegicus
770613 Gallus gallus
490349 Canis lupus familiaris
614920 Bos taurus
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