Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) ELISA试剂盒

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. 再加上,我们可以发Glycoprotein Ib (Platelet), alpha Polypeptide 抗体 (216)Glycoprotein Ib (Platelet), alpha Polypeptide 蛋白 (15)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
GP1BA 2811  
大鼠 GP1BA GP1BA 691992  
GP1BA 14723 O35930
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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
小鼠 11.72 pg/mL 46.88-3000 pg/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
$910.56
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0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
$1,026.67
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0.35 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests Log in to see 13至16个工作日
$700.00
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0.35 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests Log in to see 8至12个工作日
$928.46
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< 0.35 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests Log in to see 11至18个工作日
$838.60
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1.875 ng/mL 3.125 ng/mL - 200 ng/mL   96 Tests Log in to see 11至18个工作日
$724.89
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小鸡 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11至18个工作日
$724.89
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0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11至18个工作日
$724.89
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Pig 1.875 ng/mL 3.125 ng/mL - 200 ng/mL   96 Tests Log in to see 11至18个工作日
$724.89
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适于 Glycoprotein Ib (Platelet), alpha Polypeptide 相互作用对的更多 ELISA 试剂盒

Human Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 (显示 LMAN1 ELISA试剂盒) or MCFD2 (显示 MCFD2 ELISA试剂盒)

  2. ERK5 associates with CKII (显示 CSNK2A1 ELISA试剂盒) to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) pathway.

  3. There was no evidence to suggest that polymorphisms of GP VI T13254C and GP Ibalpha VNTR were associated with CAD (显示 CAD ELISA试剂盒).

  4. analysis of an artificial botrocetin that can inhibit the VWF (显示 VWF ELISA试剂盒)-GPIb interaction

  5. Loss of the platelet surface receptors GPIbalpha and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions

  6. Very low birth weight preterm neonates have increased numbers of platelets interacting with von Willebrand Factor (显示 VWF ELISA试剂盒), and increased GPIbalpha expression on the platelet surface

  7. Data suggest that an aspartate at position 1261 is the most critical residue of VWF (显示 VWF ELISA试剂盒) N-terminal linker for inhibiting binding of VWF (显示 VWF ELISA试剂盒) A1 domain to GP1BA on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF (显示 VWF ELISA试剂盒) A1 domain lock N-terminal linker in place such that binding to GP1BA is reduced.

  8. Data show that von Willebrand factor (VWF (显示 VWF ELISA试剂盒)) is first converted from a compact to linear form by flow, and is subsequently activated to bind platelet glycoprotein Ib alpha polypeptide (GPIbalpha) in a tension-dependent manner.

  9. The >30 nm macroglycopeptide separating the two domains of GPIbalpha transmits force on the VWF (显示 VWF ELISA试剂盒)-GPIbalpha bond (whose lifetime is prolonged by leucine-rich repeat domain unfolding) to the juxtamembrane mechanosensitive domain to enhance its unfolding, resulting in unfolding cooperativity at an optimal force.

  10. Meta-analysis found that glycoprotein Ia (显示 MMRN1 ELISA试剂盒) C807T T allele or the TT genotype, the Ser (显示 SIGLEC1 ELISA试剂盒)-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.

Cow (Bovine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. both the gpIb-VWF (显示 VWF ELISA试剂盒) interaction and the integrin alpha(2 (显示 ITGA2 ELISA试剂盒))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (显示 GSTA3 ELISA试剂盒))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (显示 VWF ELISA试剂盒) is bound

Mouse (Murine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background

  2. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin (显示 F2 ELISA试剂盒)

  3. Thrombin (显示 F2 ELISA试剂盒) cleavage of platelet PAR4 (显示 F2RL3 ELISA试剂盒) promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha.

  4. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process.

  5. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts.

  6. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF (显示 VWF ELISA试剂盒)-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis.

  7. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF (显示 VWF ELISA试剂盒) interactions.

  8. Platelet IKKbeta (显示 IKBKB ELISA试剂盒) deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding.

  9. these data demonstrate that coordinated expression of GPIbalpha and filamin (显示 FLNA ELISA试剂盒) is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.

  10. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage.

Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) 抗原简介

Antigen Summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Gene names and symbols associated with GP1BA

  • glycoprotein Ib platelet alpha subunit (GP1BA) 抗体
  • glycoprotein Ib (platelet), alpha polypeptide (GP1BA) 抗体
  • glycoprotein Ib platelet alpha subunit (Gp1ba) 抗体
  • glycoprotein 1b, alpha polypeptide (Gp1ba) 抗体
  • BDPLT1 抗体
  • BDPLT3 抗体
  • BSS 抗体
  • CD42B 抗体
  • CD42b-alpha 抗体
  • DBPLT3 抗体
  • GP1B 抗体
  • GP1BA 抗体
  • GPIba 抗体
  • GPIbalpha 抗体
  • VWDP 抗体

Protein level used designations for GP1BA

GP-Ib alpha , antigen CD42b-alpha , platelet glycoprotein Ib alpha chain , platelet membrane glycoprotein 1b-alpha subunit , glycoprotein Ib (platelet), alpha polypeptide , platelet glycoprotein Ib alpha polypeptide , GPIb-alpha , GPIbA , glycoprotein Ibalpha , glycoprotein 1b, alpha polypeptide , platelet glycoprotein Ib alpha chain-like

GENE ID SPECIES
2811 Homo sapiens
504977 Bos taurus
468166 Pan troglodytes
403638 Canis lupus familiaris
420059 Gallus gallus
691992 Rattus norvegicus
14723 Mus musculus
100717535 Cavia porcellus
100857333 Gallus gallus
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