Glycophorin B (MNS Blood Group) 蛋白 (GYPB)

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. 再加上,我们可以发Glycophorin B (MNS Blood Group) 抗体 (36)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GYPB 2994 P06028
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
小麦胚 非结合性   2 μg Log in to see 11至12个工作日

GYPB 蛋白 by Origin and Source

Origin 在表达 标记
Human ,

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Human Glycophorin B (MNS Blood Group) (GYPB) interaction partners

  1. A novel c.166A>T (p.Thr56Ser) mutation in GYPB*S decreases S antigen expression.

  2. a complex structural rearrangement involving the loss of GYPB and gain of two GYPB-A hybrid genes reduces the risk of severe malaria by 40% and has recently increased in frequency in parts of Kenya

  3. through bioinformatic analysis, identified extensive variation in GYPB transcript levels in individuals from Benin, suggesting selection from malaria pressure; collective data suggest that the GPA and GPB receptors are of greater importance than the GPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum

  4. MNSs blood group glycophorin variants in Taiwan: a genotype-serotype correlation study of 'Mi(a)' and St(a) with report of two new alleles for St(a).

  5. A novel GYPB mutation (c.270+5G>A) accounting for the S-s-U+(var) phenotype was identified.

  6. Substitution of GPB with Gp.Mur significantly reduced the expression of Rh antigen and RhAG on the Mi.III(+/+) erythrocyte membrane

  7. an increased susceptibility to infection by this parasite is associated with the glycophorin B S+ variant in Brazilian Amazons

  8. Indochina I strain of P. falciparum is not dependent on glycophorin B to invade erythrocytse through a trypsin-resistant pathway as are the strains 3D7, HB3, and Dd2.

  9. The S-s-U+var phenotype arises from changes in or around GYPB exon 5.

  10. GYPA & GYPB genotypes carrying MNSs antigens were analyzed in Thai patients with cerebral malaria & mild malaria; no statistical difference was found; it is concluded that MNSs antigens do not reveal the difference in susceptibility to cerebral malaria

  11. Alternative to conventional tube technique for mass screening for MNS hybrids, especially when specific antisera are not available.

  12. Immunoblotting showed the presence of monomer and dimer forms of a GP(A-B) hybrid and an absence of GPA and GPB. Sequencing of DNA and PCR-RFLP using the restriction enzyme RsaI confirmed the presence of a hybrid GYP(AB).

  13. The erythrocyte-binding domain, region 2 of EBL-1, bound glycophorin B(+) but

  14. This study reports for the first time the molecular mechanisms responsible for the S-s- phenotype in a population of African Brazilians and provides new information about the frequency and molecular bases of the GYPB*S silent gene in this population.

蛋白简介Glycophorin B (MNS Blood Group) (GYPB)


Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta\\\\; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.

Gene names and symbols associated with GYPB

  • glycophorin B (MNS blood group) (GYPB)
  • CD235b 蛋白
  • GPB 蛋白
  • GPB.NY 蛋白
  • GpMiIII 蛋白
  • GYPHe.NY 蛋白
  • HGpMiIII 蛋白
  • HGpMiVI 蛋白
  • HGpMiX 蛋白
  • MNS 蛋白
  • PAS-3 蛋白
  • SS 蛋白

Protein level used designations for GYPB

SS-active sialoglycoprotein , Ss blood group , glycophorin HeP2 , glycophorin MiIII , glycophorin MiVI , glycophorin MiX , glycophorin-B , sialoglycoprotein delta

2994 Homo sapiens
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