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Receptor for gastrin releasing peptide (GRP).
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These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis .
ablating GRP (显示 UCMA ELISA试剂盒) receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially
Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling.
BNP-NPRA (显示 NPR1 ELISA试剂盒) signaling is involved in both itch and pain and does not function upstream of the GRP (显示 UCMA ELISA试剂盒)-GRPR dedicated neuronal pathway.
The present results suggest that BB2 receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling.
spinal GRPr and NMBr independently drive itch neurotransmission in mice.
GRPR and stathmin (显示 STMN1 ELISA试剂盒) control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex
Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders.
The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization
We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-knockout mice
GRP/GRP-R signaling activation contributes to castration-resistant prostate cancer progression
Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters
Our results suggest that, similar to what happens in neutrophils, gastrin-releasing peptide (显示 GRP ELISA试剂盒) is a migratory, rather than a proliferative, stimulus, for non-small cell lung carcinoma cells, indicating a putative role for gastrin-releasing peptide (显示 GRP ELISA试剂盒) and gastrin-releasing peptide receptor in metastasis
GRP-R regulates glucose metabolism in neuroblastoma by modulating HIF-1alpha, PDK4 and PDP2.
BBS caused a significant increase in Shh (显示 SHH ELISA试剂盒) gene transcription and protein secretion that was dependent on BBS-induced GPCR (显示 NMUR1 ELISA试剂盒)/Galphaq (显示 GNAQ ELISA试剂盒)-//Rho mediated activation of nuclear factor kappaB (NFkappaB (显示 NFKB1 ELISA试剂盒)), which can stimulate a NF-kappaB (显示 NFKB1 ELISA试剂盒) response element in the Shh (显示 SHH ELISA试剂盒) gene promoter
No association of 16 GRP and 7 GRPR variants were found with agoraphobia with/without panic disorder.
GRPR is highly expressed in epidermoid carcinoma of the anal canal, suggesting this receptor might have a role in anal carcinogenesis.
a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG (显示 PRB3 ELISA试剂盒)-RhoA (显示 RHOA ELISA试剂盒)-ROCK pathway.
GRPR expression was more pronounced in an advanced-stage lung cancer
integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
gastrin-releasing peptide receptor
, gastrin-releasing peptide receptor-like
, GRP-preferring bombesin receptor
, bombesin receptor