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feedback between the level of ghrelin and gastrin in the blood of patients with chronic gastritis and type 2 diabetes mellitus; with increasing levels of gastrin in the blood, the level of ghrelin in the blood decreases and vice versa
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The same markers were also expressed in a proportion of adenocarcinomas supporting the view that gastrin is important in the development of gastric cancer
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We concluded that low serum gastrin is related to increased risk of ER(+) BC development. The results also established that CCKBR/ERK/P65 signaling function is generally tumor suppressive in ER(+) BC, indicating therapies should focus on restoring, not inhibiting, CCKBR/ERK/P65 pathway activity.
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Study reveals that Galphas binds to RGS1 and plays a necessary role during RGS1mediated promotion of melanoma proliferation and migration.
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Gastrin and BCL2 apoptosis regulator (Bcl2) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features.
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Everolimus down-regulates the systemic levels of gastrin and glucagon in patients with pancreatic neuroendocrine tumors.
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we suggest that gastrin contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1
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Results demonstrate that gastrin increases the expression of the autophagy markers MAP1LC3B-II and SQSTM1 in gastric adenocarcinoma cells. Gastrin induces autophagy via activation of the STK11-PRKAA2-ULK1 and that this signaling pathway is involved in increased migration and cell survival.
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PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis.
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Gastrin is expressed in both insulin(+) and somatostatin(+) cells in adults with type 2 diabetes.
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Gastrin induced ABCG2 expression by activating NF-kappaB and thereby modulated the side population proportion, tumor cell metastatic potential and invasion activity in pancreatic cancer.
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CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells.
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Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin, glucagon, and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.
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Gastrin role in gastric epithelial homeostasis and gastric carcinogenesis
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Results suggest a role for Toll-like receptor 4 in gastric acid regulation and that the Toll-like receptor 4 (TLR4) +896 and +1196 wild type homozygozity increases peptic ulcer risk via gastrin secretion.
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Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17]
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treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene)).
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Gastrin stimulates MMP-1 expression in gastric epithelial cells and stimulates cell migration.
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Progastrin is a new pro-angiogenic factor in colorectal cancer and an attractive therapeutic target.
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Small (=10 mm) gastric carcinoids with normal serum gastrin level confined to submucosa can be treated with endoscopic or local resection unless lymphovascular invasion.