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Induces apoptosis.. 再加上，我们可以发Gasdermin A 蛋白 (4)和数多这个蛋白质的别的产品。
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GSDMA is upregulated in systemic sclerosis monocyte-derived macrophages but not in the skin; and is an expression quantitative trait locus in systemic sclerosis macrophages and lipopolysaccharide/interferon gamma (IFNgamma)-stimulated monocytes. A systemic sclerosis macrophage transcriptome signature is characterized by upregulation of glycolysis, hypoxia and mTOR signaling and a downregulation of IFNgamma response pat...
modest changes (8-13%) in promoter methylation levels of ZPBP2 and GSDMA may cause substantial changes in RNA levels and allelic expression of ZPBP2 and ORMDL3 is mediated by DNA methylation
GSDMA was identified as a susceptibility gene for systemic sclerosis.
we investigated the association between GSDMA and GSDMB variants and the incidence of adult and childhood asthma among Jordanians.An association between the GSDMB T/C single nucleotide polymorphism (SNP) genotype and the incidence of childhood asthma was found
The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately.
Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation
Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA, MED24, and PSMD3 in European continent (EA) subjects.
The GSDMA (rs7212938) and GSDMB (rs7216389) polymorphisms are associated with asthma susceptibility and intermediate asthma phenotypes.
Results suggest an association of 17q21 polymorphisms with ORMDL3, GSDMA expression, and IL-17 secretion early in life. These observations may imply a functional role of the 17q21 locus affecting T-cell development during immune maturation.
The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis.
Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers.
Evolutionary recombination hotspot around the GSDML-GSDM locus is closely linked to oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12.
, gasdermin A1
, gasdermin A