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GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. 再加上，我们可以发GDP Dissociation Inhibitor 1 抗体 (88) 和 GDP Dissociation Inhibitor 1 蛋白 (14)和数多这个蛋白质的别的产品。
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Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA.
Human oligodendrogliomas cells stably expressing mutant GDI1 showed altered cell proliferation.
The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target
GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers.
The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype.
A model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway.
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
RhoGDI has a role in inactivating Rho GTPases with ExoS RhoGAP
isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA
RhoGDI overexpression is associated with paclitaxel resistance in ovarian cancers
The results of case-control analysis indicated that, no association between the rs11549300 polymorphisms of GDI1 and children NSMR (P >0.05), but its polymorphisms may be related to intelligence levels of children in Qinba region (P =0.03).
GDI-1 is preferentially involved in insulin-stimulated glucose transporter 4 (GLUT4) translocation through facilitating Rab10 recycling.
Study used cognitive protocols with high translational validity to human condition that target the functionality of cortico-striatal circuitry such as attention and stimulus selection ability with progressive degree of complexity; showed that that Gdi1-null mice are impaired in attention and associative learning processes.
Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA/Gdi1 (human or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA/Gdi1.
A pivotal role of alphaGDI via specific RAB GTPases acting specifically in forebrain regions at the pre-synaptic sites involved in memory formation.
Lack of alphaGDI impairs synaptic vesicle biogenesis and recycling in the hippocampus.
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.
, guanosine diphosphate dissociation inhibitor 1
, mental retardation, X-linked 48
, protein XAP-4
, rab GDI alpha
, rab GDP dissociation inhibitor alpha
, rab GDP-dissociation inhibitor, alpha
, Rab GDIalpha
, GDP-dissociation inhibitor 1
, SMG p25A GDI
, Guanosine diphosphate dissociation inhibitor 1
, Rab GDI alpha