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The protein encoded by FOXK2 contains a fork head DNA binding domain. 再加上，我们可以发Forkhead Box K2 抗体 (69)和数多这个蛋白质的别的产品。
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FOXK2, regulted by miR (显示 MLXIP 蛋白)-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma
SOX9 (显示 SOX9 蛋白) transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer.FOXK2 is highly expressed in colorectal cancer tissues.
Results show that Foxk2 expression was downregulated in lung adenocarcinoma tissues and non-small cell lung cancer cell (NSCLC) lines. Its overexpression suppresses epithelial-mesenchymal transition in NSCLC cells and inhibits cell migration and invasion. Also, the expression of Foxk2 seems to be regulated by miR (显示 MLXIP 蛋白)-1271.
FOXO3 (显示 FOXO3 蛋白)-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 (显示 FOXO3 蛋白) where both factors play a regulatory role.
FOXK2 might act as a negative regulator of ERalpha (显示 ESR1 蛋白), and its association with both ERalpha (显示 ESR1 蛋白) and BRCA1/BARD1 (显示 BARD1 蛋白) could lead to the down-regulation of ERalpha (显示 ESR1 蛋白) transcriptional activity, effectively regulating the function of ERalpha (显示 ESR1 蛋白).
FOXK1 and FOXK2 positively regulate Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling by translocating dishevelled (显示 DVL2 蛋白) proteins into the nucleus.
BAP1 (显示 RNF2 蛋白) deficiency causes increased expression of FoxK2 target genes in a Ring1B (显示 RNF2 蛋白)-Bmi1 (显示 BMI1 蛋白)-dependent manner
FOXK2 can promote transcriptional activation and is required for the efficient recruitment of AP-1 (显示 FOSB 蛋白) components to chromatin.
Data show that FOXK2 is subject to control by cell cycle-regulated hyperphosphorylation occurring in CDK (显示 CDK4 蛋白)).cyclin (显示 PCNA 蛋白)-dependent manner with CDK1 (显示 CDK1 蛋白).cyclin B as the major kinase complex.
FOXK2 is a G/T-mismatch DNA-binding protein (显示 UBE2V1 蛋白) and a deaminated DNA-binding protein (显示 UBE2V1 蛋白)
FoxK2 is required for proliferation and survival.
Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.
, cellular transcription factor ILF-1
, forkhead box protein K2
, interleukin enhancer binding factor 1
, interleukin enhancer-binding factor 1
, forkhead box K2