Forkhead Box D3 蛋白 (FOXD3)

FOXD3 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. 再加上,我们可以发FOXD3 抗体 (91)FOXD3 试剂盒 (12)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FOXD3 27022 Q9UJU5
FOXD3 15221 Q61060
大鼠 FOXD3 FOXD3 29203  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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FOXD3 蛋白 by Origin and Source

Origin 在表达 标记
Human

Mouse (Murine)

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Zebrafish Forkhead Box D3 (FOXD3) interaction partners

  1. Foxd3 rescues the prdm1a loss-of-function neural crest phenotype.

  2. These results reveal dynamic and differential regulation of FoxD3 in distinct neural crest subpopulations, suggesting that heterogeneity is encrypted at the regulatory level

  3. analysis of how a FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specification

  4. tfap2a and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm

  5. analysis of a Foxd3/mitfa transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate

  6. foxd3 is an essential Nodal-dependent regulator of zebrafish mesoderm development.

  7. Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.

  8. zebrafish Foxd3 is necessary for the differentiation of a subset of neural crest cell fates, perhaps in precursors of particular neural crest lineages.

  9. Foxd3, a well-known regulator in neural crest development, is also involved in myf5 regulation

  10. Foxd3 selectively specifies premigratory neural crest cells for a neuronal, glial or cartilage fate by inducing the expression of lineage-associated transcription factors in these cells and regulating their subsequent migration.

  11. employed genetic linkage analysis and physical mapping to place the mosm188 mutation on chromosome 6 in the vicinity of the foxd3 gene

  12. colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis.

  13. Ectopic expression of foxd3 indicates that foxd3 promotes early melanophore death only when kit is inactive

  14. Data suggest the presence of Foxd3 in a subset of precursors leads to mitfa repression and suppression of melanophore fate.

  15. Disc1 functions in the transcriptional repression of foxd3 and sox10, thus mediating cranial neural crest cell migration and differentiation.

Human Forkhead Box D3 (FOXD3) interaction partners

  1. FOXD3 acts as a repressor of the mitochondrial S-adenosylmethionine carrier (SLC25A26) gene expression in cancer cells.

  2. On the basis of these data, FOXD3 is a potent repressor of DCLK1-S expression in normal cells; loss of FOXD3 in hCCCs/hCRCs allows upregulation of DCLK1-S, imparting a potent invasive potential to the cells

  3. FOXD3 knockdown resulted in enhanced ATC proliferation, invasion and migration and diminished cellular apoptosis. Further, we showed that FOXD3 regulated expression of E-cadherin by modulating MAPK/EKR signaling pathway that promotes EMT and metastasis during thyroid carcinogenesis.

  4. Results show that FOXD3 expression was reduced in colon cancer cells. Its knockdown dramatically increased the proliferation of tumor cells, enhanced cell invasiveness and inhibited cell apoptosis. The study indicates that FOXD3 may play a protective role in human colon formation by regulating EGFR/Ras/Raf/MEK/ERK signal pathway.

  5. FOXO4 and FOXD3 were shown independently predictive of overall survival in gastric cancer

  6. FOXD3/miR-214/MED19 axis is important for the regulation of growth, invasion and metastasis of colorectal cancer

  7. total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers

  8. Results showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis.

  9. FOXD3 is sufficient but not necessary to drive PAX3 expression in melanoma cells.

  10. The present study finds that the aspirin-FOXD3-OLA1P2-STAT3 axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use

  11. FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for high-grade gliomas, which warrant further investigation.

  12. Down-regulation of FOXD3 is associated with metastasis in hepatocellular carcinoma.

  13. Data show that transcription factors PAX3 and FOXD3-mediated melanoma cell migration is dependent on promoting the expression of chemokine receptor CXCR4.

  14. In addition to a possible association of rs78645479 in FoxD3 with vitiligo, our data on the association of this FoxD3 variant with thyroid autoantibodies suggest a potential involvement of FoxD3 in thyroid immunoregulation.

  15. FOXD3 overexpression significantly inhibits cell growth and results in G1 cell cycle arrest in NSCLC A549 and H1299 cells.

  16. FOXD3 and TWIST1 define distinct subgroups of cells within a heterogeneous tumor.

  17. Findings indicate that miR-137 is a valuable biomarker for hepatocellular carcinoma (HCC) prognosis and the forkhead box D3 (FoxD3)/miR-137/AKT2 regulatory network plays an important role in HCC progression.

  18. Results suggest an inverse relationship between FoxD3 expression and tumor metastasis in invasive ductal carcinomas of the breast.

  19. Results indicate that FOXD3 exhibits tumor suppressive activity that affects the growth, aggressiveness and angiogenesis of NB through transcriptional regulation of NDRG1.

  20. Our results indicate FOXD3 exhibits tumor suppressive activity and may be useful for breast therapy.

Mouse (Murine) Forkhead Box D3 (FOXD3) interaction partners

  1. FOXD3-AS1 serves as a sponge or as a competing endogenous noncoding RNA for miR-150, restricting its capability to promote cell growth and thereby exaggerating hyperoxia-induced lung epithelial cell death

  2. suggest that CHD7, Oct3/4, Sox2, and Nanog directly induce FoxD3 expression when stimulated by BMP2/Wnt3a signaling, that FoxD3 promotes Sox10 expression, and that histone H3K4 methylation play important roles in this process of neural crest-derived stem cell formation

  3. this study shows that Foxd3 suppresses the production of IL-10+ Breg cells by directly binding the IL-10 promoter

  4. Foxd3 poises enhancers in pluripotent stem cells by recruiting multiple epigenetic enzymes that together simultaneously initiate and repress enhancer activity.

  5. analysis of a cycle of activation and deactivation of Foxd3 required for exit from naive pluripotency and subsequent primordial germ cell specification

  6. Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells

  7. In a xenograft tumor model, FOXD3 overexpression inhibits tumor growth and angiogenesis.

  8. Data indicate that homeobox b5 (Hoxb5) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3).

  9. Foxd3 induced mutant ESCs precociously express genes required for mesoderm induction, but they are likely unable to differentiate into skeletal muscle.

  10. Data indicate that growth factor receptor protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3), and pregulated Grb2 interacts with huntingtin (Htt).

  11. Foxd3 deficiency completely abolishes the sphere-forming potential of skin embryonic stem cells.

  12. Foxd3 is part of a dynamically expressed gene network that is necessary and sufficient to regulate fate decisions in premigratory neural crest cells.

  13. Methylation profile analyses identified the promoter of FOXD3 as the only genomic region with increased methylation in mice and humans during progression of Helicobacter pylori-associated gastric tumors.

  14. The findings highlighted the crucial roles played by Foxd3 during enteric nervous system development including progenitor proliferation, neural patterning, and glial differentiation.

  15. Foxd3 is upstream of several pathways critical for beta-cell mass expansion in vivo.

  16. Foxd3 and Pax3 act together to affect survival and maintenance of cardiac NC progenitors, and loss of these progenitors catastrophically affects key aspects of later cardiovascular development.

  17. show that Foxd3 mediates a fate restriction choice for multipotent neural crest (NC) progenitors with loss of Foxd3 biasing NC toward a mesenchymal fate

  18. In ESCs, binding of Foxd3 suppresses intergenic transcription of the enhancer and surrounding sequences.

  19. Trophoblast progenitors in Foxd3-/- embryos do not self-renew and are not multipotent, but instead give rise to an excess of trophoblast giant cells.

蛋白简介FOXD3

蛋白简介

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.

Gene names and symbols associated with Forkhead Box D3 蛋白 (FOXD3)

  • forkhead box D3 (foxd3)
  • forkhead box D3 (FOXD3)
  • forkhead box D3 (Foxd3)
  • AIS1 蛋白
  • CWH3 蛋白
  • fkd6 蛋白
  • fkh6 蛋白
  • forkhead-6 蛋白
  • FOXD3 蛋白
  • Genesis 蛋白
  • Hfh2 蛋白
  • VAMAS2 蛋白
  • XFD-6 蛋白
  • xfoxd3 蛋白
  • zgc:111934 蛋白

Protein level used designations for Forkhead Box D3 蛋白 (FOXD3)

fork head domain protein 6 , forkhead box protein D3 , mother superior , forkhead box D3 , HNF3/FH transcription factor genesis , HFH-2 , HNF-3/forkhead homolog 2 , hepatocyte nuclear factor 3 forkhead homolog 2 , winged helix protein CWH-3 , winged-helix protein CWH-3

GENE ID SPECIES
30548 Danio rerio
456905 Pan troglodytes
496851 Xenopus (Silurana) tropicalis
696085 Macaca mulatta
100301607 Oryzias latipes
27022 Homo sapiens
489558 Canis lupus familiaris
532383 Bos taurus
15221 Mus musculus
29203 Rattus norvegicus
395794 Gallus gallus
101102030 Ovis aries
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