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FOXD3 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. 再加上，我们可以发FOXD3 抗体 (89) 和 FOXD3 试剂盒 (12)和数多这个蛋白质的别的产品。
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Foxd3 rescues the prdm1a (显示 PRDM1 蛋白) loss-of-function neural crest phenotype.
These results reveal dynamic and differential regulation of FoxD3 in distinct neural crest subpopulations, suggesting that heterogeneity is encrypted at the regulatory level
analysis of how a FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specification
tfap2a (显示 TFAP2A 蛋白) and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a (显示 TFAP2A 蛋白) is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm
analysis of a Foxd3/mitfa (显示 MITF 蛋白) transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate
foxd3 is an essential Nodal-dependent regulator of zebrafish mesoderm development.
Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.
zebrafish Foxd3 is necessary for the differentiation of a subset of neural crest cell fates, perhaps in precursors of particular neural crest lineages.
Foxd3, a well-known regulator in neural crest development, is also involved in myf5 (显示 MYF5 蛋白) regulation
Foxd3 selectively specifies premigratory neural crest cells for a neuronal, glial or cartilage fate by inducing the expression of lineage-associated transcription factors in these cells and regulating their subsequent migration.
On the basis of these data, FOXD3 is a potent repressor of DCLK1 (显示 DCLK1 蛋白)-S expression in normal cells; loss of FOXD3 in hCCCs/hCRCs allows upregulation of DCLK1 (显示 DCLK1 蛋白)-S, imparting a potent invasive potential to the cells
FOXD3 knockdown resulted in enhanced ATC (显示 SRPK1 蛋白) proliferation, invasion and migration and diminished cellular apoptosis. Further, we showed that FOXD3 regulated expression of E-cadherin (显示 CDH1 蛋白) by modulating MAPK (显示 MAPK1 蛋白)/EKR signaling pathway that promotes EMT (显示 ITK 蛋白) and metastasis during thyroid carcinogenesis.
Results show that FOXD3 expression was reduced in colon cancer cells. Its knockdown dramatically increased the proliferation of tumor cells, enhanced cell invasiveness and inhibited cell apoptosis. The study indicates that FOXD3 may play a protective role in human colon formation by regulating EGFR (显示 EGFR 蛋白)/Ras/Raf (显示 RAF1 蛋白)/MEK (显示 MAP2K1 蛋白)/ERK (显示 EPHB2 蛋白) signal pathway.
FOXO4 (显示 FOXO4 蛋白) and FOXD3 were shown independently predictive of overall survival in gastric cancer
FOXD3/miR (显示 MLXIP 蛋白)-214/MED19 (显示 MED19 蛋白) axis is important for the regulation of growth, invasion and metastasis of colorectal cancer
total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers
Results showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis.
FOXD3 is sufficient but not necessary to drive PAX3 (显示 PAX3 蛋白) expression in melanoma cells.
The present study finds that the aspirin-FOXD3-OLA1P2-STAT3 (显示 STAT3 蛋白) axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use
FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for high-grade gliomas, which warrant further investigation.
FOXD3-AS1 (显示 ARSB 蛋白) serves as a sponge or as a competing endogenous noncoding RNA for miR (显示 MLXIP 蛋白)-150, restricting its capability to promote cell growth and thereby exaggerating hyperoxia-induced lung epithelial cell death
suggest that CHD7 (显示 CHD3 蛋白), Oct3/4 (显示 POU5F1 蛋白), Sox2 (显示 SOX2 蛋白), and Nanog (显示 NANOG 蛋白) directly induce FoxD3 expression when stimulated by BMP2 (显示 BMP2 蛋白)/Wnt3a (显示 WNT3A 蛋白) signaling, that FoxD3 promotes Sox10 (显示 SOX10 蛋白) expression, and that histone H3K4 methylation play important roles in this process of neural crest-derived stem cell formation
this study shows that Foxd3 suppresses the production of IL-10 (显示 IL10 蛋白)+ Breg cells by directly binding the IL-10 (显示 IL10 蛋白) promoter
Foxd3 poises enhancers in pluripotent stem cells by recruiting multiple epigenetic enzymes that together simultaneously initiate and repress enhancer activity.
analysis of a cycle of activation and deactivation of Foxd3 required for exit from naive pluripotency and subsequent primordial germ cell specification
Foxd3 suppresses NFAT (显示 NFATC1 蛋白)-mediated differentiation to maintain self-renewal of embryonic stem cells
In a xenograft tumor model, FOXD3 overexpression inhibits tumor growth and angiogenesis.
Data indicate that homeobox b5 (Hoxb5 (显示 HOXB5 蛋白)) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3).
Foxd3 induced mutant ESCs (显示 NR2E3 蛋白) precociously express genes required for mesoderm induction, but they are likely unable to differentiate into skeletal muscle.
Data indicate that growth factor receptor (显示 RYK 蛋白) protein binding protein 2 (Grb2 (显示 GRB2 蛋白)) is upregulated and regulated by Forkhead Box D3 (Foxd3), and pregulated Grb2 (显示 GRB2 蛋白) interacts with huntingtin (Htt (显示 HTT 蛋白)).
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.
fork head domain protein 6
, forkhead box protein D3
, mother superior
, forkhead box D3
, HNF3/FH transcription factor genesis
, HNF-3/forkhead homolog 2
, hepatocyte nuclear factor 3 forkhead homolog 2
, winged helix protein CWH-3
, winged-helix protein CWH-3