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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases.
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Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1 (显示 TGFB1 ELISA试剂盒)-induced E-cadherin (显示 CDH1 ELISA试剂盒) down-regulation.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination.
SCF (显示 KITLG ELISA试剂盒)(FBXL19) targets RhoA (显示 RHOA ELISA试剂盒) for its disposal, a process regulated by Erk2 (显示 MAPK1 ELISA试剂盒).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (显示 IL33 ELISA试剂盒)-mediated activity by removing ST2L (显示 TMED1 ELISA试剂盒), but not sST2 (显示 SSTR2 ELISA试剂盒) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, jumonji C domain-containing histone demethylase 1C
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like