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Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (By similarity)..
Showing 10 out of 42 products:
Human Polyclonal ETV2 Primary Antibody for ELISA - ABIN408656
Knebel, De Haro, Janknecht: Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. in Journal of cellular biochemistry 2006
Data have identified the Xenopus ortholog of er71 and could show that er71 function in Xenopus is required for vasculogenesis, but not for the development of hematopoietic cells.
An essential role for ETV2 in endothelial development.
These results demonstrate the requirement for Etv2 and Fli1b in tumor angiogenesis.
low levels of Vegf (显示 VEGFA 抗体) signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf (显示 VEGFA 抗体) signaling promote arterial and inhibit venous specification.
results suggest that the LSD1 (显示 KDM1A 抗体)-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Etv2 alone is required for early vasculogenesis, whereas Etv2 and Fli1b function redundantly during late vasculogenesis and early embryonic angiogenesis.
The results identify an etv2 cis (显示 CISH 抗体)-regulatory mechanism controlling cardiovascular fate choice implying that etv2 participates in a transcriptional network mediating developmental plasticity of endothelial progenitor cells during embryonic development.
etv2 has a critical cell autonomous requirement during neutropoiesis in the anterior lateral plate mesoderm.
etv2 acts during early development to specify endothelial lineages and is then down-regulated, in part through post-transcriptional repression by microRNAs, to allow normal vascular development.
Expression of Etv2 alone is sufficient to transdifferentiate fast skeletal muscle into functional endothelial cells in vivo.
substantially increased number of candidate genes regulated by etsrp in vascular cells
Identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast.
REVIEW. the interplay among the ETS transcription factor (显示 FEV 抗体) ETV2, vascular endothelial growth factor (显示 VEGF 抗体), and its receptor VEGFR2/FLK1 (显示 KDR 抗体) is essential for hematopoietic and vascular development. Emerging studies also support the role of these three factors and possible interplay in hematopoietic and vascular regeneration.
Single-factor ETV2 transduction successfully reprogrammed dermal fibroblasts into functional EPCs.
ETV2 alone can directly reprogram postnatal cells to functional, mature endothelial cells.
ets variant 2 (ETV2) alone directly converts primary human adult skin fibroblasts into functional vascular endothelial cells.
identify human Etv2/ER71 and mouse ER71 proteins as functional orthologs of Etsrp (显示 ETS1 抗体)
HIF1alpha (显示 HIF1A 抗体) activation of Etv2 in embryonic stem cells followed by NOTCH1 (显示 NOTCH1 抗体) signaling is required for the generation arterial endothelial cells that are capable of arteriogenesis and revascularization of ischemic tissue.
This study aimed to evaluate the effects of the E-twenty six (ETS (显示 ETS1 抗体)) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia.
Foxh1 (显示 FOXH1 抗体) regulated FLK1 (显示 KDR 抗体)+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.
findings demonstrate a critical role for Etv2-miR (显示 MLXIP 抗体)-130a-Jarid2 (显示 JARID2 抗体) in vascular patterning both in vitro and in vivo
These findings demonstrate that Etv2 is an important regulator of hematopoietic regeneration.
Study discuss the functional significance of ETV2 in embryonic vessel development, postnatal angiogenesis and direct cell reprogramming. [review]
Etv2 transactivates miR (显示 MLXIP 抗体)-130a in the endothelial progenitors.
Endothelial ETV2 is required for postnatal vascular repair and regeneration.
studies define upstream and downstream networks that serve as a transcriptional rheostat to regulate Etv2 gene expression
These findings highlight the critical role that transient ETV2 expression plays in the regulation of hematopoietic and endothelial cell lineage specification and stability.
Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA-3' (By similarity).
ETS translocation variant 2
, ets variant 2
, ets variant gene 2
, Ets1-related protein
, v-ets erythroblastosis virus E26 oncogene homolog 1b
, ets-related protein 71
, ets related protein 71