Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2) ELISA试剂盒

EMR2 encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. 再加上,我们可以发Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 抗体 (94)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
EMR2 30817 Q9UHX3
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适于 Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 相互作用对的更多 ELISA 试剂盒

Chimpanzee Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2) interaction partners

  1. Results show a pattern of increasing EMR2 expression in higher grade gliomas and demonstrate an association of overexpressing EMR2 tumors with poor survival in all grades of glioma

Human Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2) interaction partners

  1. miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population.

  2. EMR2 expression levels correlated with CTP scores and increased further in cirrhotic patients with infections. These high EMR2-expressed neutrophils had activated phenotype but with deranged functions. Higher levels of these EMR2-expressed neutrophils correlated with infectious complications and predict mortality.

  3. Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively.

  4. We identified a previously unknown missense substitution in ADGRE2 which was predicted to result in the replacement of cysteine with tyrosine as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds.

  5. Using the myeloid cell-restricted EMR2 receptor as a paradigm, we exam the mechanistic relevance of the subunit interaction and demonstrate a critical role for autoproteolysis in mediating receptor signaling and cell activation

  6. a functional role for EMR2 in the modulation of neutrophil activation during inflammation.

  7. High EMR2 is associated with invasive phenotype in glioblastoma.

  8. The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer.

  9. complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages

  10. epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans

  11. role of the extracellular stalk and the G protein-coupled receptor proteolysis site motif in EMR2 processing

  12. Site-directed mutagenesis of the P(+1) cleavage site (Ser(518)) shows an absolute requirement of a Ser, Thr, or Cys residue for efficient proteolysis.

  13. The results presented here further support the idea that EMR2 plays a role in the migration and adhesion of myeloid cells during cell differentiation, maturation, and activation.

  14. Here we demonstrate how the human-restricted adhesion-GPCR EMR2 regulates neutrophil responses by potentiating the effects of a number of proinflammatory mediators and show that the transmembrane region is critical for adhesion-GPCR function.

  15. EGF-TM7 pre-mRNAs also undergo the rare trans-splicing, leading to the generation of functional chimeric receptors.

Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2) 抗原简介

Antigen Summary

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with EMR2

  • adhesion G protein-coupled receptor E2 (ADGRE2) 抗体
  • adhesion G protein-coupled receptor E2 (LOC484898) 抗体
  • CD312 抗体
  • EMR2 抗体

Protein level used designations for EMR2

egf-like module containing, mucin-like, hormone receptor-like 2 , EGF-like module-containing mucin-like hormone receptor-like 2 , EGF-like module containing, mucin-like, hormone receptor-like sequence 2 , EGF-like module receptor 2

GENE ID SPECIES
455788 Pan troglodytes
484898 Canis lupus familiaris
30817 Homo sapiens
610750 Canis lupus familiaris
654420 Macaca mulatta
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