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The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. 再加上，我们可以发ENPP2 试剂盒 (28) 和 ENPP2 蛋白 (14)和数多这个蛋白质的别的产品。
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Results demonstrated, for the first time, that increased serum ATX activity and protein levels are associated with several aspects of quality of life in cholestatic patients as well as with markers of cholestatic liver injury and higher risks of death and transplantation. The study provides novel clinical evidence of the pruritogenic role of the ATX/lysophosphatidic acid axis in the pathogenesis of cholestatic itch.
ENPP2 silencing increased HBV replication approximately 2.3-fold by enhancing, via the type I IFN signaling pathway, HBV cccDNA (covalently closed circular DNA) translation into viral RNA.
This study demonstrated that Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes.
Structural and functional studies have revealed what makes ATX a unique lysoPLD, and how secreted ATX binds to its target cells. The ATX catalytic domain shows a characteristic bimetallic active site followed by a shallow binding groove that can accommodate nucleotides as well as the glycerol moiety of lysophospholipids, and by a deep lipid-binding pocket.
We conclude that an ATM-ATX axis interconnects double-strand breaks with silica-induced inflammation and propagates these effects in epithelial cells
we present a new crystal structure of ATX in complex with orthovanadate (ATX-VO5), which binds the Ogamma nucleophile of Thr209 and adopts a trigonal bipyramidal conformation, following the nucleophile attack onto the substrate.We propose that ATX follows the associative two-step in-line displacement mechanism.
The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed.
These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.
LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels
AKT (显示 AKT1 抗体) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (显示 NFATC3 抗体)-mediated p23 (Sec24C (显示 SEC24C 抗体)) expression
Data show that autotaxin (ATX)-mediated autocrine lipid signaling promotes naive pluripotency by intersecting with LIF (显示 LIF 抗体) and BMP4 (显示 BMP4 抗体) signaling.
ENPP2 links Activin-A (显示 INHBA 抗体) enhanced mTOR (显示 FRAP1 抗体) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.
Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.
These results indicate that ATX-lysophosphatidic acid-LPA3 (显示 LPAR3 抗体) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (显示 HBEGF 抗体) and COX-2 (显示 COX2 抗体) pathways.
ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (显示 CYP11A1 抗体)) and enables 2 major mediators of SSc (显示 CYP11A1 抗体) fibrogenesis, lysophosphatidic acid and IL-6 (显示 IL6 抗体), to amplify the production of each other.
These results suggest that the post-transcriptional regulation of ATX expression by HuR (显示 ELAVL1 抗体) and AUF1 (显示 HNRNPD 抗体) modulates cancer cell migration.
inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.
findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation
Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.
These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.
Autotaxin-Lysophosphatidic Acid axis acts downstream of Apoprotein (显示 APOE 抗体) B lipoproteins in endothelial cells.
When autotaxin (Atx), was overexpressed in zebrafish embryos by injecting atx mRNA, the embryos showed cardia bifida, a phenotype induced by down-regulation of sphingosine-1-phosphate signaling.
the ATX-LPA (显示 LPA 抗体)-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates
This study demonstrate that the zebrafish ortholog to mammalian atx displays evolutionarily conserved expression pattern characteristics.
results suggest a major role for the Atx/Lpar3 (显示 LPAR3 抗体) signaling axis in regulating KV formation, ciliogenesis and L-R asymmetry via a Wnt (显示 WNT2 抗体)-dependent pathway
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2
, extracellular lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2
, plasma lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
, ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog